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Revisiting Non-Cancer Drugs for Cancer Therapy
Yang E.J.; Wu C.; Liu Y.; Lv J.; Shim J.S.
2016-08-01
Source PublicationCurrent Topics in Medicinal Chemistry
ISSN18734294 15680266
Volume16Issue:19Pages:2144-2155
Abstract

Although tremendous effort has been made over the past century to treat cancer effectively, the pace of drug development is far behind the increasing rate of cancer incidence and mortality. There are two major hurdles in anticancer drug development: dose-limiting toxic side effects that reduce either drug effectiveness or the quality of life of patients and complicated drug development processes that are costly and time consuming. Drug repositioning has recently gained increasing attention among cancer researchers as this approach utilizes existing drugs and is significantly cost-and time-effective. Existing drugs, particularly non-cancer drugs, have favorable safety profiles in humans and serve as an ever-increasing source for new anticancer drug discovery. Here we review the recent examples of drug repositioning of existing non-cancer drugs for preclinical and clinical introductions of cancer therapy.

KeywordCancer Disulfiram Doxycycline Drug Repositioning Existing Drugs Mebendazole Pyrvinium Pamoate Triclosan
URLView the original
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000385547100008
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Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniversidade de Macau
Recommended Citation
GB/T 7714
Yang E.J.,Wu C.,Liu Y.,et al. Revisiting Non-Cancer Drugs for Cancer Therapy[J]. Current Topics in Medicinal Chemistry,2016,16(19):2144-2155.
APA Yang E.J.,Wu C.,Liu Y.,Lv J.,&Shim J.S..(2016).Revisiting Non-Cancer Drugs for Cancer Therapy.Current Topics in Medicinal Chemistry,16(19),2144-2155.
MLA Yang E.J.,et al."Revisiting Non-Cancer Drugs for Cancer Therapy".Current Topics in Medicinal Chemistry 16.19(2016):2144-2155.
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