UM
Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells
Meng Y.1; Ren Z.1; Xu F.1; Zhou X.1; Song C.1; Wang V.Y.-F.1; Liu W.1; Lu L.3; Thomson J.A.2; Chen G.1
2018-12-11
Source PublicationStem Cell Reports
ISSN22136711
Volume11Issue:6Pages:1347-1356
AbstractIn this report, Guokai Chen and colleagues show that nicotinamide is a kinase inhibitor with multiple targets. Nicotinamide improves human pluripotent stem cell (hPSC) survival as a ROCK inhibitor, and it also induces hPSC differentiation as a casein kinase 1 inhibitor. This discovery highlights nicotinamide's regulatory function beyond its common roles in metabolism, PARP, and sirtuin pathways.
Keywordcell differentiation cell survival human pluripotent stem cell kinase inhibitor nicotinamide
DOI10.1016/j.stemcr.2018.10.023
URLView the original
Indexed BySCI
Language英語
WOS Research AreaCell Biology
WOS SubjectCell & Tissue Engineering ; Cell Biology
WOS IDWOS:000452898300008
PublisherCELL PRESS
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Universidade de Macau
2.Morgridge Institute for Research
3.Jinan University
4.University of Wisconsin Madison
Recommended Citation
GB/T 7714
Meng Y.,Ren Z.,Xu F.,et al. Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells[J]. Stem Cell Reports,2018,11(6):1347-1356.
APA Meng Y..,Ren Z..,Xu F..,Zhou X..,Song C..,...&Chen G..(2018).Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells.Stem Cell Reports,11(6),1347-1356.
MLA Meng Y.,et al."Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells".Stem Cell Reports 11.6(2018):1347-1356.
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