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Secretin as a neurohypophysial factor regulating body water homeostasis
Chu J.Y.S.1; Lee L.T.O.1; Lai C.H.1; Vaudry H.2; Chan Y.S.1; Yung W.H.3; Chow B.K.C.1
2009-09-15
Source PublicationProceedings of the National Academy of Sciences of the United States of America
ISSN00278424 10916490
Volume106Issue:37Pages:15961-15966
AbstractHypothalamic magnocellular neurons express either one of the neurohypophysial hormones, vasopressin or oxytocin, along with different neuropeptides or neuromodulators. Axonal terminals of these neurons are generally accepted to release solely the two hormones but not others into the circulation. Here, we show that secretin, originally isolated from upper intestinal mucosal extract, is present throughout the hypothalamo- neurohypophysial axis and that it is released from the posterior pituitary under plasma hyperosmolality conditions. In the hypothalamus, it stimulates vasopressin expression and release. Considering these findings together with our previous findings that show a direct effect of secretin on renal water reabsorption, wepropose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis. Findings presented here challenge previous understanding regarding the neurohypophysis and could provide new concepts in treating disorders related to osmoregulation.
KeywordHypothalamic-pituitary axis Osmoregulation Vasopressin
DOI10.1073/pnas.0903695106
URLView the original
Language英語
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被引频次[WOS]:43   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Affiliation1.The University of Hong Kong
2.Université de Rouen Normandie
3.Chinese University of Hong Kong
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Chu J.Y.S.,Lee L.T.O.,Lai C.H.,et al. Secretin as a neurohypophysial factor regulating body water homeostasis[J]. Proceedings of the National Academy of Sciences of the United States of America,2009,106(37):15961-15966.
APA Chu J.Y.S..,Lee L.T.O..,Lai C.H..,Vaudry H..,Chan Y.S..,...&Chow B.K.C..(2009).Secretin as a neurohypophysial factor regulating body water homeostasis.Proceedings of the National Academy of Sciences of the United States of America,106(37),15961-15966.
MLA Chu J.Y.S.,et al."Secretin as a neurohypophysial factor regulating body water homeostasis".Proceedings of the National Academy of Sciences of the United States of America 106.37(2009):15961-15966.
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