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Insights into the evolution of proglucagon-derived peptides and receptors in fish and amphibians
Ng S.Y.L.; Lee L.T.O.; Chow B.K.C.
2010
Source PublicationAnnals of the New York Academy of Sciences
Volume1200
Pages15-32
AbstractGlucagon and the glucagon-like peptides (GLP-1 and GLP-2) share a common evolutionary origin and are triplication products of an ancestral glucagon exon. In mammals, a standard scenario is found where only a single proglucagon-derived peptide set exists. However, fish and amphibians have either multiple proglucagon genes or exons that are likely resultant of duplication events. Through phylogenetic analysis and examination of their respective functions, the proglucagon ligand-receptor pairs are believed to have evolved independently before acquiring specificity for one another. This review will provide a comprehensive overview of current knowledge of proglucagon-derived peptides and receptors, with particular focus on fish and amphibian species. © 2010 New York Academy of Sciences.
Keywordgene duplication glucagon glucagon-like peptides molecular evolution receptor
DOI10.1111/j.1749-6632.2010.05505.x
URLView the original
Language英語
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionFaculty of Health Sciences
AffiliationThe University of Hong Kong
Recommended Citation
GB/T 7714
Ng S.Y.L.,Lee L.T.O.,Chow B.K.C.. Insights into the evolution of proglucagon-derived peptides and receptors in fish and amphibians[C],2010:15-32.
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