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An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II
Lee V.H.Y.1; Lee L.T.O.1; Chu J.Y.S.1; Lam I.P.Y.1; Siu F.K.Y.1; Vaudry H.2; Chow B.K.C.1
2010-12-01
Source PublicationFASEB Journal
ISSN08926638 15306860
Volume24Issue:12Pages:5024-5032
AbstractFluid balance is critical to life and hence is tightly controlled in the body. Angiotensin II (ANGII), one of the most important components of this regulatory system, is recognized as a dipsogenic hormone that stimulates vasopressin (VP) expression and release. However, detailed mechanisms regarding how ANGII brings about these changes are not fully understood. In the present study, we show initially that the osmoregulatory functions of secretin (SCT) in the brain are similar to those of ANGII in mice and, more important, we discovered the role of SCT as the link between ANGII and its downstream effects. This was substantiated by the use of two knockout mice, SCTR and SCT, in which we show the absence of an intact SCT/secretin receptor (SCTR) axis resulted in an abolishment or much reduced ANGII osmoregulatory functions. By immunohistochemical staining and in situ hybridization, the proteins and transcripts of SCT and its receptor are found in the paraventricular nucleus (PVN) and lamina terminalis. We propose that SCT produced in the circumventricular organs is transported and released in the PVN to stimulate vasopressin expression and release. In summary, our findings identify SCT and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body. © FASEB.
KeywordCircumventricular organs Fluid homeostasis Secretin receptor-deficient mice Vasopressin
DOI10.1096/fj.10-165399
URLView the original
Language英語
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Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.The University of Hong Kong
2.Université de Rouen Normandie
Recommended Citation
GB/T 7714
Lee V.H.Y.,Lee L.T.O.,Chu J.Y.S.,et al. An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II[J]. FASEB Journal,2010,24(12):5024-5032.
APA Lee V.H.Y..,Lee L.T.O..,Chu J.Y.S..,Lam I.P.Y..,Siu F.K.Y..,...&Chow B.K.C..(2010).An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II.FASEB Journal,24(12),5024-5032.
MLA Lee V.H.Y.,et al."An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II".FASEB Journal 24.12(2010):5024-5032.
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