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Discovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP)
Tam J.K.V.1; Lee L.T.O.1; Cheng C.H.K.2; Chow B.K.C.1
2011
Source PublicationGeneral and Comparative Endocrinology
ISSN10956840 00166480
Volume173Issue:3Pages:405-410
AbstractPituitary adenylate cyclase-activating polypeptide (PACAP)-related peptide (PRP) is a peptide encoded with PACAP in the same precursor protein. Non-mammalian PRPs were previously termed growth hormone-releasing hormone (GHRH)-like peptide, and was regarded as the mammalian GHRH homologue in non-mammalian vertebrates until the discovery of authentic GHRH genes in teleosts and amphibians. Although a highly specific receptor for PRP, which is lost in mammals, is present in non-mammals, a clear function of PRP in vertebrates remains unknown. Using goldfish as a model, here we show the expression of PRP and its cognate receptor in the brain-pituitary-gonadal (BPG) axis, thus suggesting a function of goldfish (gf) PRP in regulating reproduction. We found that gfPRP controls the expression of reproductive hormones in the brain, pituitary and ovary. Goldfish PRP exerts stimulatory effects on the expression of salmon gonadotropin-releasing hormone (sGnRH) in the brain, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in pituitary primary culture cells, but inhibits the expression of LH in the ovary. Using the same technique, we showed that gfPRP did not alter the mRNA level of growth hormone in the pituitary primary culture. In summary, we have discovered the first function of vertebrate PRP in regulating reproduction, which provides a new research direction in studying the neuroendocrine control of reproduction not only in teleosts, but also in other non-mammalian vertebrates. © 2011 Elsevier Inc.
KeywordFollicle-stimulating hormone (FSH) Goldfish Growth hormone (GH) Luteinizing hormone (LH) PACAP-related peptide (PRP) Pituitary adenylate cyclase-activating polypeptide (PACAP)
DOI10.1016/j.ygcen.2011.06.003
URLView the original
Language英語
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.The University of Hong Kong
2.Chinese University of Hong Kong
Recommended Citation
GB/T 7714
Tam J.K.V.,Lee L.T.O.,Cheng C.H.K.,et al. Discovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP)[J]. General and Comparative Endocrinology,2011,173(3):405-410.
APA Tam J.K.V.,Lee L.T.O.,Cheng C.H.K.,&Chow B.K.C..(2011).Discovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP).General and Comparative Endocrinology,173(3),405-410.
MLA Tam J.K.V.,et al."Discovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP)".General and Comparative Endocrinology 173.3(2011):405-410.
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