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Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility
Huang, Bin1; Zhou, Zhong-Yan1,2; Li, Shang1; Huang, Xiao-Hui1; Tang, Jing-Yi2; Hoi, Maggie Pui Man1; Lee, Simon Ming Yuen1
2018-02
Source PublicationPHARMACOLOGICAL RESEARCH
ISSN1043-6618
Volume128Pages:389-398
Abstract

Defects in vascular integrity in cerebrovasculature lead to serious pathologies including hemorrhagic stroke. The stability of cell adhesion junctions and actin-myosin contractile machinery are two major determinants for the integrity of endothelial monolayer. Here we have evaluated the protective effects of tanshinone I (Tan I), a lipophilic compound presents in Salvia miltiorrhiza, against atorvastatin-induced cerebral hemorrhage in zebrafish in vivo, and further dissected the molecular mechanisms in HUVECs. We demonstrated that Tan I protected endothelial integrity by stabilizing cell cell adhesion junctions via the inhibition of Src-mediated VE-cadherin internalization and subsequent junction-linked actin cytoskeleton depolymerization. In addition, Tan I inhibited ROCK-associated endothelial contractile machinery by dephosphorylating cofilin and MYPT1. These findings identified Tan I as an endothelial stabilizing agent and suggested Tan I as a potential treatment for vascular leakage in hemorrhagic stroke.

KeywordTanshinone i Vascular Integrity Endothelial Cell Adhesion Hemorrhagic Stroke Zebrafish Huvecs
DOI10.1016/j.phrs.2017.09.025
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000435626500039
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
The Source to ArticleWOS
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHoi, Maggie Pui Man; Lee, Simon Ming Yuen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang, Bin,Zhou, Zhong-Yan,Li, Shang,et al. Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility[J]. PHARMACOLOGICAL RESEARCH,2018,128:389-398.
APA Huang, Bin.,Zhou, Zhong-Yan.,Li, Shang.,Huang, Xiao-Hui.,Tang, Jing-Yi.,...&Lee, Simon Ming Yuen.(2018).Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility.PHARMACOLOGICAL RESEARCH,128,389-398.
MLA Huang, Bin,et al."Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility".PHARMACOLOGICAL RESEARCH 128(2018):389-398.
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