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Glutathione and H2O2 consumption promoted photodynamic and chemotherapy based on biodegradable MnO2–Pt@Au25 nanosheets
Bi H.1; Dai Y.1; Yang P.1; Xu J.1; Yang D.1; Gai S.1; He F.1; An G.1; Zhong C.1; Lin J.3
2019-01-15
Source PublicationChemical Engineering Journal
ISSN13858947
Volume356Pages:543-553
Abstract

Photodynamic therapy (PDT) has become a significant anticancer method by making full use of reactive oxygen species (ROS) to kill cancer cells. However, high concentration of reductive glutathione (GSH) in tumor site is an enemy, which can decrease the PDT efficacy due to ROS consumption property of reductive GSH. To overcome the problem, here we design an innovative nanoplatform, which could integrate PDT, chemotherapy and magnetic resonance imaging (MRI) in one nanosystem. In this platform, MnO nanosheets were employed as the carrier by conjugating photosensitizer (Au nanoclusters) with platinum(IV) (Pt(IV)) prodrugs for synergistic PDT and chemotherapy. Interestingly, GSH can reduce MnO nanosheets and Pt(IV) prodrugs simultaneously. Consequently, the concentration of intercellular GSH has been greatly decreased. More importantly, Mn reduced from MnO nanosheets remarkably improves both T– and T–weighted MRI owing to high level of GSH and HO in acidic tumor microenvironment, and Pt(II) reduced from Pt(IV) gives rise to high chemotoxicity to cancer cells. Combined with high PDT efficiency by consuming large amount of intercellular GSH, this nanoplatform has successfully achieved the MRI guided synergistic therapy, which is promising for potential clinic applications in cancer therapy.

KeywordAu25 Clusters Mno2 Nanosheets Mri Photodynamic Therapy Pt(Iv) Prodrugs
DOIhttp://doi.org/10.1016/j.cej.2018.09.076
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering
WOS SubjectEngineering, Environmental ; Engineering, Chemical
WOS IDWOS:000447004100056
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Harbin Engineering University
2.Wuyi University
3.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Bi H.,Dai Y.,Yang P.,et al. Glutathione and H2O2 consumption promoted photodynamic and chemotherapy based on biodegradable MnO2–Pt@Au25 nanosheets[J]. Chemical Engineering Journal,2019,356:543-553.
APA Bi H..,Dai Y..,Yang P..,Xu J..,Yang D..,...&Lin J..(2019).Glutathione and H2O2 consumption promoted photodynamic and chemotherapy based on biodegradable MnO2–Pt@Au25 nanosheets.Chemical Engineering Journal,356,543-553.
MLA Bi H.,et al."Glutathione and H2O2 consumption promoted photodynamic and chemotherapy based on biodegradable MnO2–Pt@Au25 nanosheets".Chemical Engineering Journal 356(2019):543-553.
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