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Combination of CuS and g-C3N4 QDs on upconversion nanoparticles for targeted photothermal and photodynamic cancer therapy
Xu M.2; Yang G.2; Bi H.2; Xu J.2; Feng L.2; Yang D.2; Sun Q.2; Gai S.2; He F.2; Dai Y.2; Zhong C.2; Yang P.2
2019-03-15
Source PublicationChemical Engineering Journal
ISSN13858947
Pages866-878
AbstractCombined therapy with multimodal therapeutic agents based on nanomaterials has been shown as a promising approach to cancer treatment. In this report, a highly efficient multifunctional anti-cancer nanocomposite was fabricated by assembling a photothermal agent (CuS nanoparticles) and a photodynamic agent (g-CN quantum dots) on upconversion nanoparticles (UCNPs) after mesoporous silica coating. Then, the surface modification of the obtained nanocomposite (abbreviated as CUSCs) with polyethylene glycol (PEG) and folic acid (FA) endows the final sample (denoted as CUSCs-PEG-FA) with an excellent cancer cell targeting effect and biocompatibility. In this nanoplatform, CuS nanoparticles are an inorganic substance with low toxicity and high photothermal conversion efficiency. g-CN QDs have excellent biocompatibility and are beneficial for cellular uptake due to their small size. UCNPs can be excited by near-infrared (NIR) light to produce ultraviolet and visible (UV–vis) light emission, which overlaps with the UV absorption peak of high fluorescence g-CN quantum dots (QDs). Therefore, when the nanocomposite is excited by 808 nm NIR light, a synergistic treatment effect will be presented. Since the wavelengths absorbed by the chosen photothermal agent and the photosensitizer are different, sufficient utilization of energy can be achieved. Combining photothermal therapy (high photothermal conversion efficiency of 27.4%) and photodynamic therapy can inhibit cancer more effectively compared to any monotherapy. Moreover, as a result of the inherent performance ability of the doped rare earth ions, excellent applicability for computed tomography (CT), upconversion luminescence (UCL) and magnetic resonance imaging (MRI) has been achieved.
KeywordBiocompatibility CuS g-C3N4 Synergistic treatment Upconversion
DOI10.1016/j.cej.2018.12.052
URLView the original
Language英語
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Heihe University
2.Harbin Engineering University
Recommended Citation
GB/T 7714
Xu M.,Yang G.,Bi H.,et al. Combination of CuS and g-C3N4 QDs on upconversion nanoparticles for targeted photothermal and photodynamic cancer therapy[J]. Chemical Engineering Journal,2019:866-878.
APA Xu M..,Yang G..,Bi H..,Xu J..,Feng L..,...&Yang P..(2019).Combination of CuS and g-C3N4 QDs on upconversion nanoparticles for targeted photothermal and photodynamic cancer therapy.Chemical Engineering Journal,866-878.
MLA Xu M.,et al."Combination of CuS and g-C3N4 QDs on upconversion nanoparticles for targeted photothermal and photodynamic cancer therapy".Chemical Engineering Journal (2019):866-878.
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