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Self-assembled zinc phthalocyanine nanoparticles as excellent photothermal/photodynamic synergistic agent for antitumor treatment
Wang Z.2; Gai S.2; Wang C.2; Yang G.2; Zhong C.2; Dai Y.2; He F.2; Yang D.2; Yang P.2
2019-04-01
Source PublicationChemical Engineering Journal
ISSN13858947
Pages117-128
AbstractMultifunctional phototheranostic nanoparticles assembled from photosensitizer molecules have attracted considerable attention the field of tumor phototherapies. However, most self-assembled photosensitizer nanoparticles only exhibit photothermal therapy (PTT) activity, while their photodynamic therapy (PDT) activity is greatly restricted. Here, we first obtained nanostructured ZnPc assemblies with dual-modal PTT and PDT functions upon exposure to monochromatic 650 nm near-infrared (NIR) irradiation. The as-prepared ZnPc nanoparticles not only showed good stability, excellent biocompatibility, and absorption in the appropriate NIR region, but also exhibited high photothermal conversion efficiency (as high as 31.3%) and remarkable PDT performance. The simple synthesis method and outstanding therapeutic effect from synergistic PTT and PDT make the as-obtained ZnPc nanoparticles an ideal phototheranostic agent for effective and safe cancer treatment in clinical research.
Keyword650 nm laser Photodynamic therapy Photothermal therapy Synergistic antitumor effect ZnPc nanoparticles
DOI10.1016/j.cej.2018.12.007
URLView the original
Language英語
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Heihe University
2.Harbin Engineering University
Recommended Citation
GB/T 7714
Wang Z.,Gai S.,Wang C.,et al. Self-assembled zinc phthalocyanine nanoparticles as excellent photothermal/photodynamic synergistic agent for antitumor treatment[J]. Chemical Engineering Journal,2019:117-128.
APA Wang Z..,Gai S..,Wang C..,Yang G..,Zhong C..,...&Yang P..(2019).Self-assembled zinc phthalocyanine nanoparticles as excellent photothermal/photodynamic synergistic agent for antitumor treatment.Chemical Engineering Journal,117-128.
MLA Wang Z.,et al."Self-assembled zinc phthalocyanine nanoparticles as excellent photothermal/photodynamic synergistic agent for antitumor treatment".Chemical Engineering Journal (2019):117-128.
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