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An imaging-guided platform for synergistic photodynamic/photothermal/chemo-therapy with pH/temperature-responsive drug release
Lv R.1; Yang P.1; He F.1; Gai S.1; Yang G.1; Dai Y.1; Hou Z.2; Lin J.2
2015-09-01
Source PublicationBiomaterials
ISSN18785905 01429612
Volume63Pages:115-127
Abstract

To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell structured nano-theranostic by conjugating photosensitive Au(SR) - (SR refers to thiolate) clusters, pH/temperature-responsive polymer P(NIPAm-MAA), and anti-cancer drug (doxorubicin, DOX) onto the surface of mesoporous silica coated core-shell up-conversion nanoparticles (UCNPs). It is found that the photodynamic therapy (PDT) derived from the generated reactive oxygen species and the photothermal therapy (PTT) arising from the photothermal effect can be simultaneously triggered by a single 980 nm near infrared (NIR) light. Furthermore, the thermal effect can also stimulate the pH/temperature sensitive polymer in the cancer sites, thus realizing the targeted and controllable DOX release. The combined PDT, PTT and pH/temperature responsive chemo-therapy can markedly improve the therapeutic efficacy, which has been confirmed by both in intro and in vivo assays. Moreover, the doped rare earths endow the platform with dual-modal up-conversion luminescent (UCL) and computer tomography (CT) imaging properties, thus achieving the target of imaging-guided synergistic therapy under by a single NIR light.

KeywordPh/temperature-responsive Photodynamic Photothermal Up-conversion
DOI10.1016/j.biomaterials.2015.05.016
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000357910400011
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Citation statistics
Cited Times [WOS]:120   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Harbin Engineering University
2.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Lv R.,Yang P.,He F.,et al. An imaging-guided platform for synergistic photodynamic/photothermal/chemo-therapy with pH/temperature-responsive drug release[J]. Biomaterials,2015,63:115-127.
APA Lv R..,Yang P..,He F..,Gai S..,Yang G..,...&Lin J..(2015).An imaging-guided platform for synergistic photodynamic/photothermal/chemo-therapy with pH/temperature-responsive drug release.Biomaterials,63,115-127.
MLA Lv R.,et al."An imaging-guided platform for synergistic photodynamic/photothermal/chemo-therapy with pH/temperature-responsive drug release".Biomaterials 63(2015):115-127.
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