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NIR-driven graphitic-phase carbon nitride nanosheets for efficient bioimaging and photodynamic therapy
Feng L.1; He F.1; Yang G.1; Gai S.1; Dai Y.1; Li C.2; Yang P.1
2016
Source PublicationJournal of Materials Chemistry B
ISSN2050750X 20507518
Volume4Issue:48Pages:8000-8008
Abstract

Photodynamic therapy (PDT) is a noninvasive and promising anticancer therapy modality that utilizes the photochemical reactions of photosensitizers, upon irradiation at a specific wavelength, to yield reactive oxygen species (ROS) to impair malignant cancer cells. As a potential and new two-dimensional layered photosensitizer, graphitic-phase carbon nitride (g-CN) exhibits a high blue photoluminescence quantum yield and good biocompatibility, but is challenged by limited narrow absorption in the near-infrared (NIR) region. Herein, in order to broaden its light utilization, unique and original NIR light excited nanocomposites (g-CN/UCNP NCs) for PDT based on g-CN nanosheets combined with up-conversion nanoparticles (UCNPs) have been designed. UCNPs can efficiently convert NIR light to ultraviolet and visible light emissions that match well with the absorption of g-CN nanosheets. The nanocomposites swallowed up by cancer cells are able to yield ROS and suppress tumor cell growth and then induce apoptosis upon NIR laser excitation. This demonstrates the potential of g-CN/UCNP NCs as a low-toxic and biocompatible photosensitizer for PDT and for down/up-conversion luminescence imaging.

DOI10.1039/c6tb02232d
URLView the original
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000391778200023
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Harbin Engineering University
2.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Feng L.,He F.,Yang G.,et al. NIR-driven graphitic-phase carbon nitride nanosheets for efficient bioimaging and photodynamic therapy[J]. Journal of Materials Chemistry B,2016,4(48):8000-8008.
APA Feng L..,He F..,Yang G..,Gai S..,Dai Y..,...&Yang P..(2016).NIR-driven graphitic-phase carbon nitride nanosheets for efficient bioimaging and photodynamic therapy.Journal of Materials Chemistry B,4(48),8000-8008.
MLA Feng L.,et al."NIR-driven graphitic-phase carbon nitride nanosheets for efficient bioimaging and photodynamic therapy".Journal of Materials Chemistry B 4.48(2016):8000-8008.
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