UM  > 健康科學學院
Enhanced up/down-conversion luminescence and heat: Simultaneously achieving in one single core-shell structure for multimodal imaging guided therapy
He F.1; Feng L.1; Yang P.1; Liu B.1; Gai S.1; Yang G.1; Dai Y.1; Lin J.2
2016-10-01
Source PublicationBiomaterials
ISSN18785905 01429612
Volume105Pages:77-88
Abstract

Upon near-infrared (NIR) light irradiation, the Nd doping derived down-conversion luminescence (DCL) in NIR region and thermal effect are extremely fascinating in bio-imaging and photothermal therapy (PTT) fields. However, the concentration quenching induced opposite changing trend of the two properties makes it difficult to get desired DCL and thermal effect together in one single particle. In this study, we firstly designed a unique NaGdF:0.3%Nd@NaGdF@NaGdF:10%Yb/1%Er@NaGdF:10%Yb @NaNdF:10%Yb multiple core-shell structure. Here the inert two layers (NaGdF and NaGdF:10%Yb) can substantially eliminate the quenching effects, thus achieving markedly enhanced NIR-to-NIR DCL, NIR-to-Vis up-conversion luminescence (UCL), and thermal effect under a single 808 nm light excitation simultaneously. The UCL excites the attached photosensitive drug (Au nanoclusters) to generate singlet oxygen (O) for photodynamic therapy (PDT), while DCL with strong NIR emission serves as probe for sensitive deep-tissue imaging. The in vitro and in vivo experimental results demonstrate the excellent cancer inhibition efficacy of this platform due to a synergistic effect arising from the combined PTT and PDT. Furthermore, multimodal imaging including fluorescence imaging (FI), photothermal imaging (PTI), and photoacoustic imaging (PAI) has been obtained, which is used to monitor the drug delivery process, internal structure of tumor and photo-therapeutic process, thus achieving the target of imaging-guided cancer therapy.

KeywordCore-shell Structure Down-conversion Imaging Photothermal Up-conversion
DOI10.1016/j.biomaterials.2016.07.031
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000383299800007
全文获取链接
引用统计
被引频次[WOS]:33   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Affiliation1.Harbin Engineering University
2.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
推荐引用方式
GB/T 7714
He F.,Feng L.,Yang P.,et al. Enhanced up/down-conversion luminescence and heat: Simultaneously achieving in one single core-shell structure for multimodal imaging guided therapy[J]. Biomaterials,2016,105:77-88.
APA He F..,Feng L..,Yang P..,Liu B..,Gai S..,...&Lin J..(2016).Enhanced up/down-conversion luminescence and heat: Simultaneously achieving in one single core-shell structure for multimodal imaging guided therapy.Biomaterials,105,77-88.
MLA He F.,et al."Enhanced up/down-conversion luminescence and heat: Simultaneously achieving in one single core-shell structure for multimodal imaging guided therapy".Biomaterials 105(2016):77-88.
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
Google Scholar
中相似的文章 Google Scholar
[He F.]的文章
[Feng L.]的文章
[Yang P.]的文章
Baidu academic
中相似的文章 Baidu academic
[He F.]的文章
[Feng L.]的文章
[Yang P.]的文章
Bing Scholar
中相似的文章 Bing Scholar
[He F.]的文章
[Feng L.]的文章
[Yang P.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。