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A Versatile Near Infrared Light Triggered Dual-Photosensitizer for Synchronous Bioimaging and Photodynamic Therapy
Feng L.1; He F.1; Dai Y.1; Liu B.1; Yang G.1; Gai S.1; Niu N.4; Lv R.2; Li C.3; Yang P.1
2017-04-19
Source PublicationACS Applied Materials and Interfaces
ISSN19448252 19448244
Volume9Issue:15Pages:12993-13008
Abstract

Photodynamic therapy (PDT) based on Tm-activated up-conversion nanoparticles (UCNPs) can effectively eliminate tumor cells by triggering inorganic photosensitizers to generate cytotoxic reactive oxygen species (ROS) upon tissue penetrating near-infrared (NIR) light irradiation. However, the partial use of the emitted lights from UCNPs greatly hinders their application. Here we develop a novel dual-photosensitizer nanoplatform by coating mesoporous graphitic-phase carbon nitride (g-CN) layer on UCNPs core, followed by attaching ultrasmall Au nanoclusters and PEG molecules (named as UCNPs@g-CN-Au-PEG). The ultraviolet-visible (UV-vis) light and the intensive near infrared (NIR) emission from UCNPs can activate g-CN and excite Au nanoclusters to produce ROS, respectively, and thus realize the simultaneous activation of two kinds of photosensitizers for enhanced the efficiency of PDT mediated by a single NIR light excitation. A markedly higher PDT efficacy for the dual-photosensitizer system than any single modality has been verified by the enhanced ROS production and in vitro and in vivo results. By combining the inherent multi-imaging properties (up-conversion, CT, and MRI) of UCNPs, an imaging guided therapeutic platform has been built. As the first report of dual-inorganic-photosensitizer PDT agent, our developed system may be of high potential in future NIR light induced PDT application.

KeywordAu25 Nanoclusters G-c3n4 Imaging Photodynamic Therapy Photosensitizer Up-conversion
DOI10.1021/acsami.7b00651
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000399965700012
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Harbin Engineering University
2.Xidian University
3.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
4.Northeast Forestry University
Recommended Citation
GB/T 7714
Feng L.,He F.,Dai Y.,et al. A Versatile Near Infrared Light Triggered Dual-Photosensitizer for Synchronous Bioimaging and Photodynamic Therapy[J]. ACS Applied Materials and Interfaces,2017,9(15):12993-13008.
APA Feng L..,He F..,Dai Y..,Liu B..,Yang G..,...&Yang P..(2017).A Versatile Near Infrared Light Triggered Dual-Photosensitizer for Synchronous Bioimaging and Photodynamic Therapy.ACS Applied Materials and Interfaces,9(15),12993-13008.
MLA Feng L.,et al."A Versatile Near Infrared Light Triggered Dual-Photosensitizer for Synchronous Bioimaging and Photodynamic Therapy".ACS Applied Materials and Interfaces 9.15(2017):12993-13008.
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