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Charge convertibility and near infrared photon co-enhanced cisplatin chemotherapy based on upconversion nanoplatform
Xu J.2; Kuang Y.2; Lv R.2; Yang P.2; Li C.3; Bi H.2; Liu B.2; Yang D.2; Dai Y.2; Gai S.2; He F.2; Xing B.1; Lin J.3
2017-06-01
Source PublicationBiomaterials
ISSN18785905 01429612
Volume130Pages:42-55
AbstractOptimal nano-sized drug carrier requires long blood circulation, selective extravasation, and efficient cell uptake. Here we develop a charge-convertible nanoplatform based on Pt(IV) prodrug loaded NaYF:Yb,Tm upconversion nanoparticles (UCNs), followed by coating a layer of PEG-PAH-DMMA polymer (UCNs-Pt(IV)@PEG-PAH-DMMA). The polymer endows the platform with high biocompatibility, initial nano-size for prolonged blood circulation and selective extravasation. Especially, the anionic polymer can response to the mild acidic stimulus (pH ∼6.5) of tumor extracellular microenvironment and experience charge-shifting to a cationic polymer, resulting in electrostatic repulsion and releases of positive UCNs-Pt(IV). The positive UCNs-Pt(IV) nanoparticles have high affinity to negative cell membrane, leading to efficacious cell internalization. Simultaneously, the ultraviolet (UV) light emitted from UCNs upon near-infrared (NIR) light irradiation, together with the reductive glutathione (GSH) in cancer cells efficiently activate the Pt(IV) prodrug to highly cytotoxic Pt(II), realizing NIR photon improved chemotherapy. The experimental results reveal the charge convertibility, low adverse effect and markedly enhanced tumor ablation efficacy upon NIR laser irradiation of this smart nanoplatform. Moreover, combining the inherent upconversion luminescence (UCL) and computed tomography (CT) imaging capabilities, an alliance of cancer diagnosis and therapy has been achieved.
KeywordBioimaging Charge convertibility NIR photon Pt(IV) prodrug Upconversion
DOI10.1016/j.biomaterials.2017.03.041
URLView the original
Language英語
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Cited Times [WOS]:31   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Nanyang Technological University
2.Harbin Engineering University
3.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
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Xu J.,Kuang Y.,Lv R.,et al. Charge convertibility and near infrared photon co-enhanced cisplatin chemotherapy based on upconversion nanoplatform[J]. Biomaterials,2017,130:42-55.
APA Xu J..,Kuang Y..,Lv R..,Yang P..,Li C..,...&Lin J..(2017).Charge convertibility and near infrared photon co-enhanced cisplatin chemotherapy based on upconversion nanoplatform.Biomaterials,130,42-55.
MLA Xu J.,et al."Charge convertibility and near infrared photon co-enhanced cisplatin chemotherapy based on upconversion nanoplatform".Biomaterials 130(2017):42-55.
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