UM  > 健康科學學院
A Core–Shell-Satellite Structured Fe3O4@g-C3N4–UCNPs–PEG for T1/T2-Weighted Dual-Modal MRI-Guided Photodynamic Therapy
Feng L.1; Yang D.1; He F.1; Gai S.1; Li C.2; Dai Y.1; Yang P.1
2017-09-20
Source PublicationAdvanced Healthcare Materials
ISSN21922659 21922640
Volume6Issue:18
Abstract

Reactive oxygen species (ROS) produced in the specific tumor site plays the key role in photodynamic therapy (PDT). Herein, a multifunctional nanoplatform is designed by absorbing ultrasmall upconversion nanoparticles (UCNPs) on mesoporous graphitic-phase carbon nitride (g-CN) coated superparamagnetic iron oxide nanospheres, then further modified with polyethylene glycol (PEG)molecules (abbreviated as FeO@g-CN–UCNPs–PEG). The inert g-CN layer between FeO core and outer UCNPs can substantially depress the quenching effect of FeO on the upconversion emission. Upon near-infrared (NIR) laser irradiation, the UCNPs convert the energy to the photosensitizer (g-CN layer) through fluorescence resonance energy transfer process, thus producing a vast amount of ROS. In vitro experiment exhibits an obvious NIR-triggered cell inhibition due to the cellular uptake of nanoparticles and the effective PDT efficacy. Notably, this platform is responsive to magnetic field, which enables targeted delivery under the guidance of an external magnetic field and supervises the therapeutic effect by T/T-weighted dual-modal magnetic resonance imaging. Moreover, in vivo therapeutic effect reveals that the magnetism guided accumulation of FeO@g-CN–UCNPs–PEG can almost trigger a complete tumor inhibition without any perceived side effects. The experiments emphasize that the excellent prospect of FeO@g-CN–UCNPs–PEG as a magnetic targeted platform for PDT application.

KeywordMagnetic Targeted Mesoporous Graphitic-phase Carbon Nitride Photodynamic Reaction Oxygen Species Upconversion
DOI10.1002/adhm.201700502
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, bioMaterials
WOS IDWOS:000411265400010
Fulltext Access
Citation statistics
Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Harbin Engineering University
2.Zhejiang Normal University
Recommended Citation
GB/T 7714
Feng L.,Yang D.,He F.,et al. A Core–Shell-Satellite Structured Fe3O4@g-C3N4–UCNPs–PEG for T1/T2-Weighted Dual-Modal MRI-Guided Photodynamic Therapy[J]. Advanced Healthcare Materials,2017,6(18).
APA Feng L..,Yang D..,He F..,Gai S..,Li C..,...&Yang P..(2017).A Core–Shell-Satellite Structured Fe3O4@g-C3N4–UCNPs–PEG for T1/T2-Weighted Dual-Modal MRI-Guided Photodynamic Therapy.Advanced Healthcare Materials,6(18).
MLA Feng L.,et al."A Core–Shell-Satellite Structured Fe3O4@g-C3N4–UCNPs–PEG for T1/T2-Weighted Dual-Modal MRI-Guided Photodynamic Therapy".Advanced Healthcare Materials 6.18(2017).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Feng L.]'s Articles
[Yang D.]'s Articles
[He F.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Feng L.]'s Articles
[Yang D.]'s Articles
[He F.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Feng L.]'s Articles
[Yang D.]'s Articles
[He F.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.