UM  > 健康科學學院
Polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposite for combined photodynamic and photothermal therapy
Cai Q.2; Xu J.2; Yang D.2; Dai Y.2; Yang G.2; Zhong C.2; Gai S.2; He F.2; Yang P.2
2018
Source PublicationJournal of Materials Chemistry B
ISSN2050750X 20507518
Volume6Issue:48Pages:8148-8162
Abstract

Designing multifunctional nanoplatforms for the purpose of simultaneous theranostic modalities is critical to address the challenges of cancer therapy. Also, single modalities of phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), cannot meet the requirements of highly efficient treatment. Here, a core-shell-shell nanostructure consisting of a core of upconversion nanoparticles (UCNPs), a layer of mesoporous silica with anchored ZnO nanodots, and an outer layer of polypyrrole (PPy) was developed. In the proposed construct, the emitted ultraviolet (UV) light from the UCNPs core upon 980 nm near-infrared light irradiation can trigger the ZnO nanodots to activate ambient O molecules around cancerous tissues to produce toxic reactive oxygen species (ROS), realizing the PDT function. On the other hand, the coated PPy layer can concurrently give rise to an obvious heat effect upon NIR light illumination, thus achieving synergistic PDT and PTT effects; this results in excellent anti-tumor efficiency in vitro and in vivo. Furthermore, in hand with the upconversion luminescence (UCL) and computed tomography (CT) imaging derived from the UCNPs core, dual-mode imaging directed cancer therapy has been realized.

DOI10.1039/c8tb02407c
URLView the original
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000453224600012
Fulltext Access
Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Heihe University 164300
2.Harbin Engineering University
Recommended Citation
GB/T 7714
Cai Q.,Xu J.,Yang D.,et al. Polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposite for combined photodynamic and photothermal therapy[J]. Journal of Materials Chemistry B,2018,6(48):8148-8162.
APA Cai Q..,Xu J..,Yang D..,Dai Y..,Yang G..,...&Yang P..(2018).Polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposite for combined photodynamic and photothermal therapy.Journal of Materials Chemistry B,6(48),8148-8162.
MLA Cai Q.,et al."Polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposite for combined photodynamic and photothermal therapy".Journal of Materials Chemistry B 6.48(2018):8148-8162.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cai Q.]'s Articles
[Xu J.]'s Articles
[Yang D.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cai Q.]'s Articles
[Xu J.]'s Articles
[Yang D.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cai Q.]'s Articles
[Xu J.]'s Articles
[Yang D.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.