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Multifunctional Theranostic Nanoplatform Based on Fe-mTa2O5@CuS-ZnPc/PCM for Bimodal Imaging and Synergistically Enhanced Phototherapy
Feng L.1; Wang C.1; Li C.2; Gai S.1; He F.1; Li R.1; An G.1; Zhong C.1; Dai Y.1; Yang Z.1; Yang P.1
2018-05-07
Source PublicationInorganic Chemistry
ISSN1520510X 00201669
Volume57Issue:9Pages:4864-4876
Abstract

Multifunctional nanotheranostic agent with high performance for tumor site-specific generation of singlet oxygen (O) as well as imaging-guidance is crucial to laser-mediated photodynamic therapy. Here, we introduced a versatile strategy to design a smart nanoplatform using phase change material (PCM) to encapsulate photosensitizer (zinc phthalocyanine, ZnPc) in copper sulfide loaded Fe-doped tantalum oxide (Fe-mTaO@CuS) nanoparticles. When irradiated by 808 nm laser, the PCM is melted due to the hyperthermia effect from CuS nanoparticles, inducing the release of ZnPc to produce toxic O triggered by 650 nm light with very low power density (5 mW/cm). Then, the produced heat and toxic O can kill tumor cells in vitro and in vivo effectively. Furthermore, the special properties of Fe-mTaO endow the nanoplatform with excellent computed tomography (CT) and T-weighted magnetic resonance imaging (T-MRI) performance for guiding and real-time monitoring of therapeutic effect. This work presents a feasible way to design smart nanoplatform for controllable generation of heat and O, achieving CT/T-MRI dual-modal imaging-guided phototherapy.

DOI10.1021/acs.inorgchem.7b02959
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000431833500016
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Harbin Engineering University
2.Zhejiang Normal University
Recommended Citation
GB/T 7714
Feng L.,Wang C.,Li C.,et al. Multifunctional Theranostic Nanoplatform Based on Fe-mTa2O5@CuS-ZnPc/PCM for Bimodal Imaging and Synergistically Enhanced Phototherapy[J]. Inorganic Chemistry,2018,57(9):4864-4876.
APA Feng L..,Wang C..,Li C..,Gai S..,He F..,...&Yang P..(2018).Multifunctional Theranostic Nanoplatform Based on Fe-mTa2O5@CuS-ZnPc/PCM for Bimodal Imaging and Synergistically Enhanced Phototherapy.Inorganic Chemistry,57(9),4864-4876.
MLA Feng L.,et al."Multifunctional Theranostic Nanoplatform Based on Fe-mTa2O5@CuS-ZnPc/PCM for Bimodal Imaging and Synergistically Enhanced Phototherapy".Inorganic Chemistry 57.9(2018):4864-4876.
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