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Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model
Sun H.; Bjornmalm M.; Cui J.; Wong E.H.H.; Dai Y.; Dai Q.; Qiao G.G.; Caruso F.
2015-10-19
Source PublicationACS Macro Letters
ISSN21611653
Volume4Issue:11Pages:1205-1209
Abstract

Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular processing. Herein, we develop soft polysaccharide (hyaluronic acid, HA) replica particles and capsules with tunable stiffness and sizes similar to human red blood cells (RBCs) via atom transfer radical polymerization-mediated continuous assembly of polymers (CAP) and investigate their stiffness and deformability using colloidal-probe atomic force microscopy (CP-AFM) and a microfluidic blood capillary model, respectively. We demonstrate that HA replica particles and capsules with comparable nanoscale stiffness exhibit significantly different behaviors in a microfluidic blood capillary model. HA capsules behaved as RBCs, while HA replica particles had difficulty passing through the capillaries. These results (i) demonstrate how flow-based deformability measurements can be used to complement nanoscale stiffness measurements and (ii) provide important insight into the role of particle structure on the flow-based deformability of soft replica particles and capsules in a physiologically relevant microfluidic model.

DOI10.1021/acsmacrolett.5b00591
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
WOS IDWOS:000365147000004
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniversity of Melbourne
Recommended Citation
GB/T 7714
Sun H.,Bjornmalm M.,Cui J.,et al. Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model[J]. ACS Macro Letters,2015,4(11):1205-1209.
APA Sun H..,Bjornmalm M..,Cui J..,Wong E.H.H..,Dai Y..,...&Caruso F..(2015).Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model.ACS Macro Letters,4(11),1205-1209.
MLA Sun H.,et al."Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model".ACS Macro Letters 4.11(2015):1205-1209.
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