UM  > 健康科學學院
Self-assembly of semiconducting-plasmonic gold nanoparticles with enhanced optical property for photoacoustic imaging and photothermal therapy
Yang Z.3; Song J.1; Dai Y.1; Chen J.2; Wang F.2; Lin L.1; Liu Y.1; Zhang F.1; Yu G.1; Zhou Z.1; Fan W.1; Huang W.3; Fan Q.3; Chen X.1
2017
Source PublicationTheranostics
ISSN18387640
Volume7Issue:8Pages:2177-2185
Abstract

Although various noble metal and semiconducting molecules have been developed as photoacoustic (PA) agents, the use of semiconducting polymer-metal nanoparticle hybrid materials to enhance PA signal has not been explored. A novel semiconducting-plasmonic nanovesicle was fabricated by self-assembly of semiconducting poly(perylene diimide) (PPDI) and poly(ethylene glycol (PEG) tethered gold nanoparticles (Au@PPDI/PEG). A highly localized and strongly enhanced electromagnetic (EM) field is distributed between adjacent gold nanoparticles in the vesicular shell, where the absorbing collapsed PPDI is present. Significantly, the EM field in turn enhances the light absorption efficiency of PPDI, leading to a much greater photothermal effect and a stronger photoacoustic signal compared to PDI nanoparticle or gold nanovesicle alone. The optical property of the hybrid vesicle can be further tailored by controlling the ratio of PPDI and gold nanoparticle as well as the adjustable interparticle distance of gold nanoparticles localized in the vesicular shell. In vivo imaging and therapeutic evaluation demonstrated that the hybrid vesicle is an excellent probe for cancer theranostics.

KeywordGold Nanoparticle Perylene Diimide Photoacoustic Imaging Semiconducting-plasmonic Coupling Vesicle
DOI10.7150/thno.20545
URLView the original
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000402712500002
Fulltext Access
Citation statistics
Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Institute of Biomedical Imaging and Bioengineering
2.University of Arkansas - Fayetteville
3.Nanjing University of Post and TeleCommunications
Recommended Citation
GB/T 7714
Yang Z.,Song J.,Dai Y.,et al. Self-assembly of semiconducting-plasmonic gold nanoparticles with enhanced optical property for photoacoustic imaging and photothermal therapy[J]. Theranostics,2017,7(8):2177-2185.
APA Yang Z..,Song J..,Dai Y..,Chen J..,Wang F..,...&Chen X..(2017).Self-assembly of semiconducting-plasmonic gold nanoparticles with enhanced optical property for photoacoustic imaging and photothermal therapy.Theranostics,7(8),2177-2185.
MLA Yang Z.,et al."Self-assembly of semiconducting-plasmonic gold nanoparticles with enhanced optical property for photoacoustic imaging and photothermal therapy".Theranostics 7.8(2017):2177-2185.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang Z.]'s Articles
[Song J.]'s Articles
[Dai Y.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang Z.]'s Articles
[Song J.]'s Articles
[Dai Y.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang Z.]'s Articles
[Song J.]'s Articles
[Dai Y.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.