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Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles
Dai Y.2; Cheng S.1; Wang Z.2; Zhang R.2; Yang Z.1; Wang J.1; Yung B.C.1; Wang Z.1; Jacobson O.1; Xu C.1; Ni Q.1; Yu G.1; Zhou Z.1; Chen X.1
2018-01-23
Source PublicationACS Nano
ISSN1936086X 19360851
Volume12Issue:1Pages:455-463
Abstract

This study applies in situ production of hypochlorous acid (HOCl) to improve the therapeutic efficacy of platinum drugs. The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood. Moreover, the platinum prodrug can be reduced to cisplatin in cells and produce hydrogen peroxide (HO). The MPO catalyzes the conversion of HO to HOCl in the intercellular environment. The as-prepared MPO Pt PEG nanoparticles (MPP NPs) can be employed as a reactive oxygen species cascade bioreaction to enhance platinum drug therapy. The MPP NPs show prolonged blood circulation and high tumor accumulation as evidenced by Zr-based positron emission tomography imaging. The MPP NPs effectively inhibit tumor growth in vivo. As a first-in-class platform to harness the highly toxic HOCl in nanomedicine for cancer therapy, this strategy may open doors for further development of progressive therapeutic systems.

KeywordCisplatin Hypochlorous Acid (Hocl) Metal-polyphenol Networks Myeloperoxidase (Mpo) Positron Emission Tomography
DOI10.1021/acsnano.7b06852
URLView the original
Indexed BySCI
Language中文
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000423495200049
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Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Institute of Biomedical Imaging and Bioengineering
2.Xidian University
Recommended Citation
GB/T 7714
Dai Y.,Cheng S.,Wang Z.,et al. Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles[J]. ACS Nano,2018,12(1):455-463.
APA Dai Y..,Cheng S..,Wang Z..,Zhang R..,Yang Z..,...&Chen X..(2018).Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles.ACS Nano,12(1),455-463.
MLA Dai Y.,et al."Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles".ACS Nano 12.1(2018):455-463.
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