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Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles
Dai Y.3; Yang Z.1; Cheng S.1; Wang Z.3; Zhang R.3; Zhu G.1; Wang Z.1; Yung B.C.1; Tian R.1; Jacobson O.1; Xu C.1; Ni Q.1; Song J.1; Sun X.2; Niu G.1; Chen X.1
2018-02-22
Source PublicationAdvanced Materials
ISSN15214095 09359648
Volume30Issue:8
Abstract

Engineering functional nanomaterials with high therapeutic efficacy and minimum side effects has increasingly become a promising strategy for cancer treatment. Herein, a reactive oxygen species (ROS) enhanced combination chemotherapy platform is designed via a biocompatible metal-polyphenol networks self-assembly process by encapsulating doxorubicin (DOX) and platinum prodrugs in nanoparticles. Both DOX and platinum drugs can activate nicotinamide adenine dinucleotide phosphate oxidases, generating superoxide radicals (O ). The superoxide dismutase-like activity of polyphenols can catalyze HO generation from O . Finally, the highly toxic HO free radicals are generated by a Fenton reaction. The ROS HO can synergize the chemotherapy by a cascade of bioreactions. Positron emission tomography imaging of Zr-labeled as-prepared DOX@Pt prodrug Fe nanoparticles (DPPF NPs) shows prolonged blood circulation and high tumor accumulation. Furthermore, the DPPF NPs can effectively inhibit tumor growth and reduce the side effects of anticancer drugs. This study establishes a novel ROS promoted synergistic nanomedicine platform for cancer therapy.

KeywordCombination Therapy Metal-polyphenol Networks Positron Emission Tomography Reactive Oxygen Species Self-assembly
DOI10.1002/adma.201704877
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000425449300012
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Cited Times [WOS]:40   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Institute of Biomedical Imaging and Bioengineering
2.Xiamen University
3.Xidian University
Recommended Citation
GB/T 7714
Dai Y.,Yang Z.,Cheng S.,et al. Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles[J]. Advanced Materials,2018,30(8).
APA Dai Y..,Yang Z..,Cheng S..,Wang Z..,Zhang R..,...&Chen X..(2018).Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles.Advanced Materials,30(8).
MLA Dai Y.,et al."Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles".Advanced Materials 30.8(2018).
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