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Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo
Yang Z.3; Dai Y.1; Yin C.3; Fan Q.3; Zhang W.3; Song J.1; Yu G.1; Tang W.1; Fan W.1; Yung B.C.1; Li J.3; Li X.3; Li X.3; Tang Y.3; Huang W.3; Song J.2; Chen X.1
2018-06-06
Source PublicationAdvanced Materials
ISSN15214095 09359648
Volume30Issue:23
Abstract

Enhancing the generation of reactive oxygen species (ROS) is an effective anticancer strategy. However, it is a great challenge to control the production and to image ROS in vivo, both of which are vital for improving the efficacy and accuracy of cancer therapy. Herein, an activatable semiconducting theranostic nanoparticle (NP) platform is developed that can simultaneously enhance ROS generation while self-monitoring its levels through ratiometric photoacoustic (PA) imaging. The NP platform can further guide in vivo therapeutic effect in tumors. The theranostic NP platform is composed of: (i) cisplatin prodrug and ferric ion catalyst for ROS generation, a part of combination cancer therapy; and (ii) a ratiometric PA imaging nanoprobe consisting of inert semiconducting perylene-diimide (PDI) and ROS activatable near-infrared dye (IR790s), used in ratiometric PA imaging of ROS during cancer treatment. Ratiometric PA signals are measured at two near-infrared excitation wavelengths: 680 and 790 nm for PDI and IR790s, respectively. The measurements show highly accurate visualization of OH generation in vivo. This novel ROS responsive organic theranostic NP allows not only synergistic cancer chemotherapy but also real-time monitoring of the therapeutic effect through ratiometric PA imaging.

KeywordCisplatin Ratiometric Photoacoustic Imaging Ros Generation Synergistic Cancer Therapy Theranostics
DOI10.1002/adma.201707509
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000434036000019
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Cited Times [WOS]:38   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Institute of Biomedical Imaging and Bioengineering
2.Fuzhou University
3.Nanjing University of Post and TeleCommunications
Recommended Citation
GB/T 7714
Yang Z.,Dai Y.,Yin C.,et al. Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo[J]. Advanced Materials,2018,30(23).
APA Yang Z..,Dai Y..,Yin C..,Fan Q..,Zhang W..,...&Chen X..(2018).Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo.Advanced Materials,30(23).
MLA Yang Z.,et al."Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo".Advanced Materials 30.23(2018).
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