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Synchronous Chemoradiation Nanovesicles by X-Ray Triggered Cascade of Drug Release
Zhou Z.; Chan A.; Wang Z.; Huang X.; Yu G.; Jacobson O.; Wang S.; Liu Y.; Shan L.; Dai Y.; Shen Z.; Lin L.; Chen W.; Chen X.
2018-07-09
Source PublicationAngewandte Chemie - International Edition
ISSN15213773 14337851
Volume57Issue:28Pages:8463-8467
Abstract

The approach of concurrent-to-synchronous chemoradiation has now been advanced by well-designed nanovesicles that permit X-ray irradiation-triggered instant drug release. The nanovesicles consist of Au nanoparticles tethered with irradiation labile linoleic acid hydroperoxide (LAHP) molecules and oxidation-responsive poly(propylene sulfide)-poly(ethylene glycol) (PPS-PEG) polymers, where DOX were loaded in the inner core of the vesicles (Au-LAHP-vDOX). Upon irradiation, the in situ formation of hydroxyl radicals from LAHP molecules triggers the internal oxidation of PPS from being hydrophobic to hydrophilic, leading to degradation of the vesicles and burst release of cargo drugs. In this manner, synchronous chemoradiation showed impressive anticancer efficacy both in vitro and in a subcutaneous mouse tumor model by one-dose injection and one-time irradiation.

KeywordCancer Therapy Chemoradiation Drug Release Nanovesicles Oxidation Responsive
DOI10.1002/anie.201802351
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000437668700015
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationNational Institute of Biomedical Imaging and Bioengineering
Recommended Citation
GB/T 7714
Zhou Z.,Chan A.,Wang Z.,et al. Synchronous Chemoradiation Nanovesicles by X-Ray Triggered Cascade of Drug Release[J]. Angewandte Chemie - International Edition,2018,57(28):8463-8467.
APA Zhou Z..,Chan A..,Wang Z..,Huang X..,Yu G..,...&Chen X..(2018).Synchronous Chemoradiation Nanovesicles by X-Ray Triggered Cascade of Drug Release.Angewandte Chemie - International Edition,57(28),8463-8467.
MLA Zhou Z.,et al."Synchronous Chemoradiation Nanovesicles by X-Ray Triggered Cascade of Drug Release".Angewandte Chemie - International Edition 57.28(2018):8463-8467.
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