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Dotted Core–Shell Nanoparticles for T1-Weighted MRI of Tumors
Shen Z.2; Song J.1; Zhou Z.1; Yung B.C.1; Aronova M.A.1; Li Y.3; Dai Y.1; Fan W.1; Liu Y.1; Li Z.2; Ruan H.2; Leapman R.D.1; Lin L.1; Niu G.1; Chen X.1; Wu A.2
Source PublicationAdvanced Materials
ISSN15214095 09359648

Gd-based T -weighted contrast agents have dominated the magnetic resonance imaging (MRI) contrast agent market for decades. Nevertheless, they are reported to be nephrotoxic and the U.S. Food and Drug Administration has issued a general warning concerning their use. In order to reduce the risk of nephrotoxicity, the MRI performance of the Gd-based T -weighted contrast agents needs to be improved to allow a much lower dosage. In this study, novel dotted core–shell nanoparticles (FeGd-HN3-RGD2) with superhigh r value (70.0 mM s) and very low r /r ratio (1.98) are developed for high-contrast T -weighted MRI of tumors. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and histological analyses show good biocompatibility of FeGd-HN3-RGD2. Laser scanning confocal microscopy images and flow cytometry demonstrate active targeting to integrin αβ positive tumors. MRI of tumors shows high tumor ΔSNR for FeGd-HN3-RGD2 (477 ± 44%), which is about 6-7-fold higher than that of Magnevist (75 ± 11%). MRI and inductively coupled plasma results further confirm that the accumulation of FeGd-HN3-RGD2 in tumors is higher than liver and spleen due to the RGD2 targeting and small hydrodynamic particle size (8.5 nm), and FeGd-HN3-RGD2 is readily cleared from the body by renal excretion.

KeywordContrast Agents Dotted Core–shell Nanoparticles Longitudinal Relaxivity (R1) Magnetic Resonance Imaging Transverse Relaxivity (R2)
URLView the original
Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000441411500028
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Cited Times [WOS]:24   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Institute of Biomedical Imaging and Bioengineering
2.Chinese Academy of Sciences
3.Ningbo University
Recommended Citation
GB/T 7714
Shen Z.,Song J.,Zhou Z.,et al. Dotted Core–Shell Nanoparticles for T1-Weighted MRI of Tumors[J]. Advanced Materials,2018,30(33).
APA Shen Z..,Song J..,Zhou Z..,Yung B.C..,Aronova M.A..,...&Wu A..(2018).Dotted Core–Shell Nanoparticles for T1-Weighted MRI of Tumors.Advanced Materials,30(33).
MLA Shen Z.,et al."Dotted Core–Shell Nanoparticles for T1-Weighted MRI of Tumors".Advanced Materials 30.33(2018).
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