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Near-Infrared Semiconducting Polymer Brush and pH/GSH-Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor-Specific Phototheranostics
Yang Z.3; Fan W.2; Tang W.2; Shen Z.2; Dai Y.2; Song J.2; Wang Z.2; Liu Y.2; Lin L.2; Shan L.2; Liu Y.2; Jacobson O.2; Rong P.3; Wang W.3; Chen X.2
2018-10-22
Source PublicationAngewandte Chemie - International Edition
ISSN15213773 14337851
Volume57Issue:43Pages:14101-14105
Abstract

Tumor-specific phototheranostics is conducive to realizing precise cancer therapy. Herein, a novel tumor microenvironment (TME)-responsive phototheranostic paradigm based on the combination of semiconducting polymer brushes and polyoxometalate clusters (SPB@POM) is rationally designed. The acidic TME could drive the self-assembly of SPB@POM into bigger aggregates for enhanced tumor retention and accumulation, while the reducing TME could significantly enhance the NIR absorption of SPB@POM for significant improvement of photoacoustic imaging contrast and photothermal therapy efficacy. Therefore, the smart pH/glutathione (GSH)-responsive SPB@POM allows for remarkable phototheranostic enhancement under the unique TME, which has potential for precise tumor-specific phototheranostics with minimal side effects.

KeywordPhotoacoustic Imaging Phototheranostics Photothermal Therapy Semiconducting Polymers Tumor Microenvironment
DOI10.1002/anie.201808074
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000447371500018
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Engineering and Technology Research Center for Xenotransplantation of Human Province
2.National Institute of Biomedical Imaging and Bioengineering
3.Central South University China School of Basic Medical Sciences
Recommended Citation
GB/T 7714
Yang Z.,Fan W.,Tang W.,et al. Near-Infrared Semiconducting Polymer Brush and pH/GSH-Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor-Specific Phototheranostics[J]. Angewandte Chemie - International Edition,2018,57(43):14101-14105.
APA Yang Z..,Fan W..,Tang W..,Shen Z..,Dai Y..,...&Chen X..(2018).Near-Infrared Semiconducting Polymer Brush and pH/GSH-Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor-Specific Phototheranostics.Angewandte Chemie - International Edition,57(43),14101-14105.
MLA Yang Z.,et al."Near-Infrared Semiconducting Polymer Brush and pH/GSH-Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor-Specific Phototheranostics".Angewandte Chemie - International Edition 57.43(2018):14101-14105.
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