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Fish oil treatment reduces chronic alcohol exposure induced synaptic changes
Shi, Zhe1; Xie, Youna2; Ren, Huixia1; He, Baixuan2; Wang, Meng1; Wan, Jian-Bo1; Yuan, Ti-Fei3,4; Yao, Xiaoli2; Su, Huanxing1
2018-03-22
Source PublicationAddiction Biology
ISSN1355-6215
Volume55Issue:2Pages:1703-1713
Abstract

Alcohol addiction is a chronic neuropsychiatric disorder that represents one of the most serious global public health problems. Yet, currently there still lacks an effective pharmacotherapy. Omega-3 polyunsaturated fatty acids (N-3 PUFAs) have exhibited beneficial effects in a variety of neurological disorders, particularly in reversing behavioral deficits and neurotoxicity induced by prenatal alcohol exposure and binge drinking. In the present study, we investigated if fish oil, which is rich in N-3 PUFAs, had beneficial effects on preventing relapse and alleviating withdrawal symptoms after chronic alcohol exposure. Our results demonstrated that fish oil significantly reduced the chronic alcohol exposure-induced aberrant dendritic morphologic changes of the medium-sized spiny neurons in the core and the shell of nucleus accumbens. This inhibited the expression of AMPAR2-lacking AMPARs and their accumulation on the post synaptic membranes of medium-sized spiny neurons and eventually alleviated withdrawal symptoms and alcohol dependence. Our study therefore suggests that N-3 PUFAs are promising for treating withdrawal symptoms and alcohol dependence.

KeywordAmpar Chronic Alcohol Fish Oil Spine Synaptic Plasticity
DOIhttps://doi.org/10.1111/adb.12623
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000425624000066
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYao, Xiaoli; Su, Huanxing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China.
2.Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, China.
3.Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China.
4.Co-innovation Center of Neuroregeneration, Nantong University, China.
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Shi, Zhe,Xie, Youna,Ren, Huixia,et al. Fish oil treatment reduces chronic alcohol exposure induced synaptic changes[J]. Addiction Biology,2018,55(2):1703-1713.
APA Shi, Zhe.,Xie, Youna.,Ren, Huixia.,He, Baixuan.,Wang, Meng.,...&Su, Huanxing.(2018).Fish oil treatment reduces chronic alcohol exposure induced synaptic changes.Addiction Biology,55(2),1703-1713.
MLA Shi, Zhe,et al."Fish oil treatment reduces chronic alcohol exposure induced synaptic changes".Addiction Biology 55.2(2018):1703-1713.
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