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Enriched Endogenous Omega-3 Polyunsaturated Fatty Acids Protect Cortical Neurons from Experimental Ischemic Injury
Shi, Zhe1; Ren, Huixia1; Luo, Chuanming1; Yao, Xiaoli2; Li, Peng1; He, Chengwei1; Kang, Jing-X3; Wan, Jian-Bo1; Yuan, Ti-Fei4; Su, Huanxing5
2016-11
Source PublicationMolecular Neurobiology
ISSN0893-7648
Volume53Issue:9Pages:6482–6488
Abstract

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert therapeutic potential in a variety of neurological disorders, including ischemic stroke. However, the underlying mechanisms still lack investigation. Here, we report that cultured cortical neurons isolated from fat-1 mice with high endogenous n-3 PUFAs were tolerant to oxygen-glucose deprivation/reperfusion (OGD/R) injury. Fat-1 neurons exhibited significantly attenuated reactive oxygen species (ROS) activation induced by OGD/R injury, upregulated antiapoptotic proteins Bcl-2 and Bcl-xL, and reduced cleaved caspase-3. Exogenous administration of docosahexaenoic acid (DHA), a major component of the n-3 PUFA family, resulted in similar protective effects on cultured cortex neurons. We further verified the protective effects of n-3 PUFAs in vivo, using a mini ischemic model with a reproducible cortical

KeywordOmega-3 Polyunsaturated Fatty Acids Dha Ischemia Ros
DOIhttps://doi.org/10.1007/s12035-015-9554-y
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000387231300058
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Citation statistics
Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYuan, Ti-Fei; Su, Huanxing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
2.Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
3.Laboratory for Lipid Medicine and Technology, the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
4.School of Psychology, Nanjing Normal University, Nanjing, 210097, China. ytf0707@126.com.
5.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China. huanxingsu@umac.mo.
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Shi, Zhe,Ren, Huixia,Luo, Chuanming,et al. Enriched Endogenous Omega-3 Polyunsaturated Fatty Acids Protect Cortical Neurons from Experimental Ischemic Injury[J]. Molecular Neurobiology,2016,53(9):6482–6488.
APA Shi, Zhe.,Ren, Huixia.,Luo, Chuanming.,Yao, Xiaoli.,Li, Peng.,...&Su, Huanxing.(2016).Enriched Endogenous Omega-3 Polyunsaturated Fatty Acids Protect Cortical Neurons from Experimental Ischemic Injury.Molecular Neurobiology,53(9),6482–6488.
MLA Shi, Zhe,et al."Enriched Endogenous Omega-3 Polyunsaturated Fatty Acids Protect Cortical Neurons from Experimental Ischemic Injury".Molecular Neurobiology 53.9(2016):6482–6488.
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