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Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites
Xiao-Jia Chen1; Xiao-Jing Zhang1; Yan-Mei Shui2; Jian-Bo Wan1; Jian-Li Gao2
2016
Source PublicationEvidence-Based Complementary and Alternative Medicine
ISSN1741-427X
Volume2016
Abstract

Recently, most anticancer drugs are derived from natural resources such as marine, microbial, and botanical sources, but the low success rates of chemotherapies and the development of multidrug resistance emphasize the importance of discovering new compounds that are both safe and effective against cancer. Ginseng types, including Asian ginseng, American ginseng, and notoginseng, have been used traditionally to treat various diseases, due to their immunomodulatory, neuroprotective, antioxidative, and antitumor activities. Accumulating reports have shown that ginsenosides, the major active component of ginseng, were helpful for tumor treatment. 20(S)-Protopanaxadiol (PDS) and 20(S)-protopanaxatriol saponins (PTS) are two characteristic types of triterpenoid saponins in ginsenosides. PTS holds capacity to interfere with crucial metabolism, while PDS could affect cell cycle distribution and prodeath signaling. This review aims at providing an overview of PTS and PDS, as well as their metabolites, regarding their different anticancer effects with the proposal that these compounds might be potent additions to the current chemotherapeutic strategy against cancer.

DOIhttp://dx.doi.org/10.1155/2016/5738694
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000379446600001
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau
2.Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xiao-Jia Chen,Xiao-Jing Zhang,Yan-Mei Shui,et al. Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites[J]. Evidence-Based Complementary and Alternative Medicine,2016,2016.
APA Xiao-Jia Chen,Xiao-Jing Zhang,Yan-Mei Shui,Jian-Bo Wan,&Jian-Li Gao.(2016).Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites.Evidence-Based Complementary and Alternative Medicine,2016.
MLA Xiao-Jia Chen,et al."Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites".Evidence-Based Complementary and Alternative Medicine 2016(2016).
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