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Boronic acid derived salicylidenehydrazone complexes for wash-free fluorescence imaging of cellular organelles
Zhang, Boyu; Feng, Gang; Wang, Shichao; Zhang, Xuanjun
2018-02
Source PublicationDYES AND PIGMENTS
ISSN0143-7208
Volume149Pages:356-362
Abstract

Wash-free fluorescence imaging process has intrinsic nature of monitoring biochemical process in real time fashion and enable us to get more insight on living organism. In this contribution, it was proved that boronic acid derived salicylidenehydrazone complexes (BSs) are suitable candidates for wash-free fluorescence labels. Through pre-installation of organelles' targeting group morpholine and triphenylphosphonium (TPP+) on phenyboronic acid and then assembly it with salicylidenehydrazone ligand by dehydration and dative N-B bond, Lyso-BS and Mito-BS were acquired, which were shown to selectively stain lysosomes and mitochondria with circumventing tedious wash-off procedures in Hela cells respectively, without inducing any appreciable cytotoxicity. Our findings indicate that BSs are potential candidates as wash-free fluorescent stains.

KeywordWash-free Boronic Acid Salicylidenehydrazone Lysosomes Mitochondria Fluorescence Imaging
DOI10.1016/j.dyepig.2017.10.027
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Engineering ; Materials Science
WOS SubjectChemistry, Applied ; Engineering, Chemical ; Materials Science, Textiles
WOS IDWOS:000423246900042
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniv Macau, Fac Hlth Sci, Macau, Macau, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Zhang, Boyu,Feng, Gang,Wang, Shichao,et al. Boronic acid derived salicylidenehydrazone complexes for wash-free fluorescence imaging of cellular organelles[J]. DYES AND PIGMENTS,2018,149:356-362.
APA Zhang, Boyu,Feng, Gang,Wang, Shichao,&Zhang, Xuanjun.(2018).Boronic acid derived salicylidenehydrazone complexes for wash-free fluorescence imaging of cellular organelles.DYES AND PIGMENTS,149,356-362.
MLA Zhang, Boyu,et al."Boronic acid derived salicylidenehydrazone complexes for wash-free fluorescence imaging of cellular organelles".DYES AND PIGMENTS 149(2018):356-362.
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