UM  > 中華醫藥研究院
Entry inhibitors for AIDS therapy: A review of research and development projects
Xiangjun Kong; Hongyu Liang; Qingwen Yuan; Yuanjia Hu
2017
Source PublicationInnovation Value Chain of Chinese Pharmaceuticals
Author of SourceYitao Wang, Yuanjia Hu, Albert Wai-Kit Chan
Publication PlaceWhitestone, New York
PublisherUnited States-China Intellectual Property Institute Inc.
Pages115-134
Abstract

The HIV (human immunodeficiency virus) entry process, the first step of the HIV replication cycle, plays a significant role in the subsequent viral infections and human immune system collapse. Virus binding and entrance into the host cell involves multiple steps, including viral attachment, co-receptor interactions, and membrane fusion. This sequence of events offers several potential targets for therapeutic interference. Some antiretroviral drugs that interact with different targets involved in the entry process have been tested in various phases, but only two of them were approved for clinical application. This study attempts to provide an overall research and development (R&D) landscape of HIV entry inhibitors by reviewing relevant projects (78 projects were collected for this study). The entry inhibitors have been divided into three classes based on their functional targets: attachment inhibitors, co-receptor inhibitors, and fusion inhibitors. The development profiles are integrated to provide a clinical overview of entry inhibitors. Furthermore, the performance of each class of inhibitor in clinical trials is summarized to demonstrate their specific roles in anti-HIV therapy.

Language英语
ISBN978-0-9862198-4-9
Fulltext Access
Document TypeBook chapter
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xiangjun Kong,Hongyu Liang,Qingwen Yuan,et al. Entry inhibitors for AIDS therapy: A review of research and development projects. Whitestone, New York:United States-China Intellectual Property Institute Inc.,2017:115-134.
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