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Miniaturized video-rate epi-third-harmonic-generation fiber-microscope
Chia, SH1,2; Yu, CH1,2; Lin, CH1,2; Cheng, NC1,2; Liu, TM3; Chan, MC1,2; Chen, IH1,2; Sun, CK1,2,4
2010
Source PublicationOPTICS EXPRESS
ISSN1094-4087
Volume18Issue:16Pages:17382-17391
Abstract

With a micro-electro-mechanical system (MEMS) mirror, we successfully developed a miniaturizedepi-third-harmonic-generation (epi-THG) fiber-microscope with a video frame rate (31Hz), which was designed for in vivo optical biopsy of human skin. With a large-mode-area (LMA) photonic crystal fiber (PCF) and a regular microscopic objective, the nonlinear distortion of the ultrafast pulses delivery could be much reduced while still achieving a 0.4 mu m lateral resolution for epi-THG signals. In vivo real time virtual biopsy of the Asian skin with a video rate (31Hz) and a sub-micron resolution was obtained. The result indicates that this miniaturized system was compact enough for the least invasive hand-held clinical use. (C) 2010 Optical Society of America

DOIhttp://dx.doi.org/10.1364/OE.18.017382
Indexed BySCI
Language英语
WOS Research AreaOptics
WOS SubjectOptics
WOS IDWOS:000281042400111
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Citation statistics
Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Natl Taiwan Univ, Grad Inst Photon & Optoelect, Taipei 10617, Taiwan
2.Natl Taiwan Univ, Dept Elect Engn, Taipei 10617, Taiwan
3.Natl Taiwan Univ, Inst Biomed Engn, Taipei 10617, Taiwan
4.Acad Sinica, Res Ctr Appl Sci, Taipei 115, Taiwan
Recommended Citation
GB/T 7714
Chia, SH,Yu, CH,Lin, CH,et al. Miniaturized video-rate epi-third-harmonic-generation fiber-microscope[J]. OPTICS EXPRESS,2010,18(16):17382-17391.
APA Chia, SH.,Yu, CH.,Lin, CH.,Cheng, NC.,Liu, TM.,...&Sun, CK.(2010).Miniaturized video-rate epi-third-harmonic-generation fiber-microscope.OPTICS EXPRESS,18(16),17382-17391.
MLA Chia, SH,et al."Miniaturized video-rate epi-third-harmonic-generation fiber-microscope".OPTICS EXPRESS 18.16(2010):17382-17391.
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