UM  > 中華醫藥研究院
One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy
Yang, Yu1; Xu, Ligeng2; Zhu, Wenjun2; Feng, Liangzhu1; Liu, Jingjing2; Chen, Qian2; Dong, Ziliang2; Zhao, Jiayue2; Liu, Zhuang2; Chen, Meiwan1
2018-02
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume156Pages:121-133
Abstract

Nanoscale coordination polymers (NCPs) are promising nanomedicine platforms featured with biodegradability and versatile functionalities. However, multi-step post-synthesis surface modification is usually required to functionalize as-made NCPs before their biomedical applications. Moreover, efforts are still required to design therapeutic NCPs responsive to the unique tumor microenvironment to achieve more specific and effective therapy. Herein, we uncover a simple yet general strategy to synthesize a series of polyethylene glycol (PEG) modified NCPs via a one-step method by adding polyhistidine-PEG co-polymer into the mixture of metal ions and organic ligands during NCPs formation. With NCPs consisting Ca2+/dicarboxylic cisplatin (IV) prodrug as the example, we show that such Ca/Pt(IV)@pHis-PEG NCPs are highly sensitive to pH changes. With slightly negative charges and compact structure under pH 7.4 during blood circulation, those NCPs exhibit efficient passive accumulation in the tumor, in which the reduced pH (c.a. 6.5) would trigger charge conversion and size expansion to enhance their tumor retention and cell internationalization. After cellular uptake, NCPs within cell endo-/lysosomes with further reduced pH would then lead to decomposition of those NCPs and thus drug release. Chemotherapy with Ca/Pt(IV)@pHis-PEG NCPs in our animal tumor model demonstrates great efficacy under low drug doses, and is found to be particularly effective towards solid tumors with reduced pH. (C) 2017 Published by Elsevier Ltd.

KeywordNanoscale Coordination Polymers (Ncps) One-pot Synthesis Carrier-free Drug Delivery System Ph-responsive Charge-switching Chemotherapy
DOI10.1016/j.biomaterials.2017.11.038
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000419539100010
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yang, Yu,Xu, Ligeng,Zhu, Wenjun,et al. One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy[J]. BIOMATERIALS,2018,156:121-133.
APA Yang, Yu.,Xu, Ligeng.,Zhu, Wenjun.,Feng, Liangzhu.,Liu, Jingjing.,...&Chen, Meiwan.(2018).One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy.BIOMATERIALS,156,121-133.
MLA Yang, Yu,et al."One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy".BIOMATERIALS 156(2018):121-133.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Yu]'s Articles
[Xu, Ligeng]'s Articles
[Zhu, Wenjun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Yu]'s Articles
[Xu, Ligeng]'s Articles
[Zhu, Wenjun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Yu]'s Articles
[Xu, Ligeng]'s Articles
[Zhu, Wenjun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.