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One-step shell polymerization of inorganic nanoparticles and their applications in SERS/nonlinear optical imaging
Liu, TM1,2; Yu, JS3; Chang, CA4,5,6; Chiou, A5,6; Chiang, HK5,6,7; Chuang, YC8; Wu, CH1,2; Hsu, CH3; Chen, PA5; Huang, CC5,6,9
2014
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume4
Abstract

Surface functionalized nanoparticles have found their applications in several fields including biophotonics, nanobiomedicine, biosensing, drug delivery, and catalysis. Quite often, the nanoparticle surfaces must be post-coated with organic or inorganic layers during the synthesis before use. This work reports a generally one-pot synthesis method for the preparation of various inorganic-organic core-shell nanostructures (Au@polymer, Ag@polymer, Cu@polymer, Fe3O4@polymer, and TiO2@polymer), which led to new optical, magnetic, and catalytic applications. This green synthesis involved reacting inorganic precursors and poly(styrene-alt-maleic acid). The polystyrene blocks separated from the external aqueous environment acting as a hydrophobic depot for aromatic drugs and thus illustrated the integration of functional nanoobjects for drug delivery. Among these nanocomposites, the Au@polymer nanoparticles with good biocompatibility exhibited shell-dependent signal enhancement in the surface plasmon resonance shift, nonlinear fluorescence, and surface-enhanced Raman scattering properties. These unique optical properties were used for dual-modality imaging on the delivery of the aromatic photosensitizer for photodynamic therapy to HeLa cells.

DOIhttp://dx.doi.org/10.1038/srep05593
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000338626300007
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Cited Times [WOS]:35   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Natl Taiwan Univ, Inst Biomed Engn, Taipei 106, Taiwan
2.Natl Taiwan Univ, Mol Imaging Ctr, Taipei 106, Taiwan
3.Natl Taiwan Univ, Dept Chem Engn, Taipei 106, Taiwan
4.Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan
5.Natl Yang Ming Univ, Inst Biophoton, Taipei 112, Taiwan
6.Natl Yang Ming Univ, Biophoton & Mol Imaging Res Ctr, Taipei 112, Taiwan
7.Natl Yang Ming Univ, Inst Biomed Engn, Taipei 112, Taiwan
8.Natl Synchrotron Radiat Res Ctr, Hsinchu 300, Taiwan
9.Natl Univ Kaohsiung, Dept Appl Chem, Kaohsiung 811, Taiwan
Recommended Citation
GB/T 7714
Liu, TM,Yu, JS,Chang, CA,et al. One-step shell polymerization of inorganic nanoparticles and their applications in SERS/nonlinear optical imaging[J]. SCIENTIFIC REPORTS,2014,4.
APA Liu, TM.,Yu, JS.,Chang, CA.,Chiou, A.,Chiang, HK.,...&Huang, CC.(2014).One-step shell polymerization of inorganic nanoparticles and their applications in SERS/nonlinear optical imaging.SCIENTIFIC REPORTS,4.
MLA Liu, TM,et al."One-step shell polymerization of inorganic nanoparticles and their applications in SERS/nonlinear optical imaging".SCIENTIFIC REPORTS 4(2014).
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