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Efficient near-IR hyperthermia and intense nonlinear optical imaging contrast on the gold nanorod-in-shell nanostructures
Hu, KW1,2; Liu, TM3; Chung, KY1,2; Huang, KS4; Hsieh, CT3; Sun, CK5,6; Yeh, CS1,2
2009
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
Volume131Issue:40Pages:14186–14187
Abstract

New gold nanorod(Au NR)-in-shell nanostructures were developed to be more efficacious than Au NRs in near-IR (NIR) hyperthermia and nonlinear optical imaging contrast. Au NR-in-shell nanostructures are composed of an intact Au NR in a Au/Ag nanoshell. These nanostructures have a broad, intense absorption band that extends from 400 nm to 900 nm in the NIR. They are more efficient and efficacious than Au NRs with respect to in vitro hypothermia performance. Au NR-in-shell-labeled cancer cells were destroyed using continuous-wave NIR radiation with 50% less laser power than needed for Au NRs. Noticeably, the area of the destroyed cells was significantly larger than the size of the laser irradiation beam; in contrast, the destroyed area was usually restricted to the size of the laser beam spot when Au NRs were used. With their extraordinarily broad and strong surface plasmon resonance band, Au NR-in-shell nanostructures efficiently augmented several multiphoton nonlinear processes as well. The multiphoton emission spectrum covered almost theentire visible wavelength. The yield of the multiphoton signals of Au NR-in-shell nanostructures was on average 55 times larger than that of Au NRs. In vitro images of cancer cells targeted by Au NR-in-shell nanostructures revealed a stronger multiphoton contrast than those targeted by Au NRs.

DOIhttp://dx.doi.org/10.1021/ja9062772
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000271271500030
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Citation statistics
Cited Times [WOS]:100   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan
2.Natl Cheng Kung Univ, Ctr Frontier Mat & Micro Nano Sci & Technol, Tainan 701, Taiwan
3.Natl Taiwan Univ, Inst Biomed Engn, Taipei 106, Taiwan
4.Shou Univ, Dept Biomed Engn, Kaohsiung 840, Taiwan
5.Natl Taiwan Univ, Dept Elect Engn, Taipei 106, Taiwan
6.Natl Taiwan Univ, Grad Inst Photon & Optoelect, Taipei 106, Taiwan
Recommended Citation
GB/T 7714
Hu, KW,Liu, TM,Chung, KY,et al. Efficient near-IR hyperthermia and intense nonlinear optical imaging contrast on the gold nanorod-in-shell nanostructures[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2009,131(40):14186–14187.
APA Hu, KW.,Liu, TM.,Chung, KY.,Huang, KS.,Hsieh, CT.,...&Yeh, CS.(2009).Efficient near-IR hyperthermia and intense nonlinear optical imaging contrast on the gold nanorod-in-shell nanostructures.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,131(40),14186–14187.
MLA Hu, KW,et al."Efficient near-IR hyperthermia and intense nonlinear optical imaging contrast on the gold nanorod-in-shell nanostructures".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131.40(2009):14186–14187.
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