UM  > 中華醫藥研究院
Alleviating the hepatotoxicity of trazodone via supramolecular encapsulation
Huang, Qiaoxian; Li, Shengke; Yin, Hang; Wang, Chunming; Lee, Simon M. Y.; Wang, Ruibing
2018-02
Source PublicationFOOD AND CHEMICAL TOXICOLOGY
ISSN0278-6915
Volume112Pages:421-426
Abstract

In order to develop a novel strategy to alleviate the inherent hepatotoxicity of antidepressant trazodone (TZ), Cucurbit[7]uril (CB[7]) was adopted as pharmaceutical excipients and was studied for its capability to reduce the hepatotoxicity of TZ via supramolecular encapsulation. CB[7] was found to form strong 1:1 host-guest complexes with TZ and its metabolite m-chlorophenyl piperazine (mCPP), with binding constants of 1.50 (0.13) x 10(6) M-1 and 6.90 (+/- 0.49) x 10(5) M-1, respectively. The supramolecular complexations were examined by H-1 NMR and UV-visible spectroscopic titration, ESI-MS and ITC. In the presence of 0.5 mM CB[7], the IC50 values of TZ and mCPP on a human normal liver cell line L02 were increased from 215.5 +/- 3.3 mu M to 544.1 +/- 51.2 mu M, and from 166.8 +/- 3.8 mu M to 241.7 +/- 6.8 mu M, respectively. Evaluation on a zebrafish model demonstrated that CB[7] (0.1 mM) significantly alleviated the TZ induced liver toxicity, as shown by the level of liver degeneration, liver size and yolk sac retention. Our study may provide a supramolecular strategy to alleviate the hepatotoxicity induced by TZ and its metabolite mCPP, and this strategy may be extendable to other drugs that have inherent hepatotoxicity or other adverse effects.

KeywordEncapsulation Cucurbituril Trazodone Hepatotoxicity
DOI10.1016/j.fct.2017.12.016
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000425568900047
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Ruibing
AffiliationState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang, Qiaoxian,Li, Shengke,Yin, Hang,et al. Alleviating the hepatotoxicity of trazodone via supramolecular encapsulation[J]. FOOD AND CHEMICAL TOXICOLOGY,2018,112:421-426.
APA Huang, Qiaoxian,Li, Shengke,Yin, Hang,Wang, Chunming,Lee, Simon M. Y.,&Wang, Ruibing.(2018).Alleviating the hepatotoxicity of trazodone via supramolecular encapsulation.FOOD AND CHEMICAL TOXICOLOGY,112,421-426.
MLA Huang, Qiaoxian,et al."Alleviating the hepatotoxicity of trazodone via supramolecular encapsulation".FOOD AND CHEMICAL TOXICOLOGY 112(2018):421-426.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huang, Qiaoxian]'s Articles
[Li, Shengke]'s Articles
[Yin, Hang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huang, Qiaoxian]'s Articles
[Li, Shengke]'s Articles
[Yin, Hang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huang, Qiaoxian]'s Articles
[Li, Shengke]'s Articles
[Yin, Hang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.