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The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells
Xin Chen1; Joost J. Oppenheim2
2011-08
Source PublicationIMMUNOLOGY
ISSN0019-2805
Volume133Issue:4Pages:426-433
Abstract

Cytokine receptors expressed by CD4+ FoxP3+ regulatory T cells (Treg cells) not only serve as a phenotypic marker for the identification of this important population of immunosuppressive cells, they also promote the function of Treg cells. CD25, the a-chain of interleukin-2 receptor, is a prototype of such a receptor, which enables Treg cells to be activated by interleukin-2. We and others have found that tumour necrosis factor receptor type 2 (TNFR2) is another important cytokine receptor preferentially expressed by Treg cells with important phenotypic and functional roles. TNFR2 is preferentially expressed by highly functional human and mouse Treg cells, and mediates the activating effect of TNF on Treg cells. We review here the studies of the regulation of expression of TNFR2 on functional Treg cells as well as on CD4+ FoxP3) effector T cells (Teff cells). We document the critical role of this receptor in the activation, proliferative expansion and survival of Treg cells. The contribution of TNFR2 expression on Treg and Teff cells to the beneficial and detrimental effects of anti-TNF treatment in autoimmune disorders will also be discussed.

Keywordcd4+foxp3+regulatory t Cells cd4+foxp3+effector t Cells Immunological Phenotype Immunosuppression Tumour Necrosis Factor Receptor 2
DOIhttp://doi.org/10.1111/j.1365-2567.2011.03460.x
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000292332100004
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Cited Times [WOS]:36   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXin Chen
Affiliation1.Basic Science Program, SAIC-Frederick, Inc., Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD
2.Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD, USA
Recommended Citation
GB/T 7714
Xin Chen,Joost J. Oppenheim. The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells[J]. IMMUNOLOGY,2011,133(4):426-433.
APA Xin Chen,&Joost J. Oppenheim.(2011).The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.IMMUNOLOGY,133(4),426-433.
MLA Xin Chen,et al."The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells".IMMUNOLOGY 133.4(2011):426-433.
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