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Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide
Xin Chen1,2; Lalage M Wakefield3; Joost J Oppenheim2
2014-04
Source PublicationONCOIMMUNOLOGY
ISSN2162-4011
Volume3Issue:4
Abstract

In a mouse model of breast carcinoma, the combination of cyclophosphamide and transforming growth factor β1,2,3 (TGFβ1,2,3)-targeting antibody achieved superior antineoplastic effects. This novel paradigm of synergistic chemoimmunotherapy promises to improve the clinical outcome of cancer patients with micrometastases, and thus deserves further investigation.

KeywordAnti-tgfβ Antibody Cyclophosphamide Chemoimmunotherapy
DOIhttp://doi.org/10.4161/onci.28247
Indexed BySCI
Language英语
WOS Research AreaOncology ; Immunology
WOS SubjectOncology ; Immunology
WOS IDWOS:000339955700005
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXin Chen; Joost J Oppenheim
Affiliation1.Basic Science Program; Leidos Biomedical Research, Inc.; Frederick National Laboratory for Cancer Research; Frederick, MD USA
2.Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research,National Cancer Institute, Frederick, Maryland, USA
3.Laboratory of Cancer Biology and Genetics; Center for Cancer Research; National Cancer Institute; Frederick, MD USA
Recommended Citation
GB/T 7714
Xin Chen,Lalage M Wakefield,Joost J Oppenheim. Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide[J]. ONCOIMMUNOLOGY,2014,3(4).
APA Xin Chen,Lalage M Wakefield,&Joost J Oppenheim.(2014).Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide.ONCOIMMUNOLOGY,3(4).
MLA Xin Chen,et al."Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide".ONCOIMMUNOLOGY 3.4(2014).
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