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Effects of Chinese Medicinal Components on Chemokine Receptors: Theory, Results, and Methodology
Jiang He1; Zhen-dan He2; Xin Chen1
2016-11
Source PublicationEvidence-based Research Methods for Chinese Medicine
PublisherSpringer, Singapore
Pages187-197
Abstract

Chemokine receptors are involved in a broad spectrum of physiological and pathological processes that include immune responses, inflammation, viral infection, as well as development and metastasis of cancer. Targeting of chemokine receptors has become a therapeutic strategy and the selective chemokine receptor antagonists have important therapeutic implications. One of such examples is the anti-HIV effect of inhibitors of CC-chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4). Chinese medicines (CM) have been used for the treatment of inflammatory diseases for thousands of years, however, the scientific basis for the beneficial clinical effects of CM remains to be fully understood. So far, our studies have identified a number of chemokine receptor antagonists with defined chemical structures from CM with anti-inflammatory properties. These naturally occurring compounds have in vitro activity in the blockade of binding of chemokine ligands to their receptors, and consequently inhibited the chemotactic migration of leukocytes induced by certain chemokines. Our studies indicate that the clinical efficacy of anti-inflammatory CM is at least partially attributable to their inhibitory effect on chemokine receptors. Therefore, identification of CM-derived compounds capable of targeting chemokine receptors can unveil mechanisms underlying the anti-inflammatory effect of CM, and may also lead to the development of novel therapeutic agents. This chapter summarizes and discusses some of the recent studies in this field and the relevant experimental protocols are also introduced.

KeywordChemokine Chemokine Receptor Antagonist Chinese Medicines
DOIhttp://doi.org/10.1007/978-981-10-2290-6_11
Language英语
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Document TypeBook chapter
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Jiang He,Zhen-dan He,Xin Chen. Effects of Chinese Medicinal Components on Chemokine Receptors: Theory, Results, and Methodology:Springer, Singapore,2016:187-197.
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