UM
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+ CD25+ FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells
Xin Chen1; Jeffrey J. Subleski2; Heather Kopf3; O.M. Zack Howard3; Daniela N. Männel4; Joost J. Oppenheim3
2008-05
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume180Issue:10Pages:6467-6471
Abstract

TNFR2 is predominantly expressed by a subset of human and mouse CD4+CD25+FoxP3+ Tregs. In this study, we characterized the phenotype and function of TNFR2+ Tregs in peripheral lymphoid tissues of normal and tumor bearing C57BL/6 mice. We found that TNFR2 was expressed on 30% −40% of peripheral activated/memory subset of Tregs that were most highly suppressive. In contrast, TNFR2− Tregs exhibited the phenotype of naïve cells and only had minimal suppressive activity. Although not typically considered to be Tregs, CD4+CD25−TNFR2+ cells nevertheless possessed moderate suppressive activity. Strikingly, the suppressive activity of TNFR2+ Tregs was considerably more potent than that of reportedly highly suppressive CD103+ Tregs. In the Lewis lung carcinoma model, more highly suppressive TNFR2+ Tregs accumulated intratumorally than in the periphery. Thus, TNFR2 identifies a unique subset of mouse Tregs with an activated/memory phenotype and maximal suppressive activity which may account for tumor-infiltrating lymphocyte mediated immune evasion by tumor.

Keywordt Cell Cytokine Receptor Tolerance/suppression/anergy
DOIhttp://doi.org/10.4049/jimmunol.180.10.6467
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000257507100008
Fulltext Access
Citation statistics
Cited Times [WOS]:180   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorXin Chen
Affiliation1.Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick; Center for Cancer Research, NCIFrederick, Frederick, Maryland 21702−1201
2.Laboratory of Experimental Immunology, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702−1201
3.Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702−1201
4.Institute of Immunology, University of Regensburg, Regensburg, Germany
Recommended Citation
GB/T 7714
Xin Chen,Jeffrey J. Subleski,Heather Kopf,et al. Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+ CD25+ FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells[J]. JOURNAL OF IMMUNOLOGY,2008,180(10):6467-6471.
APA Xin Chen,Jeffrey J. Subleski,Heather Kopf,O.M. Zack Howard,Daniela N. Männel,&Joost J. Oppenheim.(2008).Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+ CD25+ FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.JOURNAL OF IMMUNOLOGY,180(10),6467-6471.
MLA Xin Chen,et al."Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+ CD25+ FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells".JOURNAL OF IMMUNOLOGY 180.10(2008):6467-6471.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xin Chen]'s Articles
[Jeffrey J. Subleski]'s Articles
[Heather Kopf]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xin Chen]'s Articles
[Jeffrey J. Subleski]'s Articles
[Heather Kopf]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xin Chen]'s Articles
[Jeffrey J. Subleski]'s Articles
[Heather Kopf]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.