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Th17 cells and Tregs: unlikely allies
Xin Chen1,2; Joost J. Oppenheim2

Identification of CD4+Foxp3+ Tregs and Th17 modified the historical Th1–Th2 paradigm. Currently, the Th17–Tregs dichotomy provides a dominant conceptual framework for the comprehension of immunity/inflammation and tolerance/immunosuppression in an increasing number of diseases. Targeting proinflammatory Th17 cells or immunosuppressive Tregs has been widely considered as a promising therapeutic strategy in the treatment of major human diseases, including autoimmunity and cancer. The efficacy and safety of such therapy rely on a thorough understanding of immunobiology and interaction of these two subsets of Th cells. In this article, we review recent progress concerning complicated interplay of Th17 cells and Tregs. There is compelling evidence that Tregs potently inhibit Th1 and Th2 responses; however, the inhibitory effect of Tregs on Th17 responses is a controversial subject. There is increasing evidence showing that Tregs actually promote the differentiation of Th17 cells in vitro and in vivo and consequently, enhanced the functional consequences of Th17 cells, including the protective effect in host defense, as well as detrimental effect in inflammation and in the support of tumor growth. On the other hand, Th17 cells were also the most potent Th subset in the stimulation and support of expansion and phenotypic stability of Tregs in vivo. These results indicate that these two subsets of Th cells reciprocally stimulate each other. This bidirectional crosstalk is largely dependent on the TNF–TNFR2 pathway. These mutual stimulatory effects should be considered in devising future Th17 cell‐ and Treg‐targeting therapy.

Indexed BySCI
WOS Research AreaCell Biology ; Hematology ; Immunology
WOS SubjectCell Biology ; Hematology ; Immunology
WOS IDWOS:000335340900005
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Cited Times [WOS]:38   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Co-First AuthorXin Chen
Corresponding AuthorXin Chen; Joost J. Oppenheim
Affiliation1.Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick,Maryland, USA
2.Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research,National Cancer Institute, Frederick, Maryland, USA
Recommended Citation
GB/T 7714
Xin Chen,Joost J. Oppenheim. Th17 cells and Tregs: unlikely allies[J]. JOURNAL OF LEUKOCYTE BIOLOGY,2014,95(5):723-731.
APA Xin Chen,&Joost J. Oppenheim.(2014).Th17 cells and Tregs: unlikely allies.JOURNAL OF LEUKOCYTE BIOLOGY,95(5),723-731.
MLA Xin Chen,et al."Th17 cells and Tregs: unlikely allies".JOURNAL OF LEUKOCYTE BIOLOGY 95.5(2014):723-731.
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