UM  > 中華醫藥研究院
Corrigendum: TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis
Xin Chen,1,2; Yingjie Nie2; Haitao Xiao2,3; Zhaoxiang Bian3; Anthony J. Scarzello2; Na-Young Song2; Anna L. Trivett2; De Yang2; Joost J. Oppenheim2
2016-10
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6
Abstract

There is now compelling evidence that TNFR2 is constitutively expressed on CD4+ Foxp3+ regulatory T cells (Tregs) and TNF-TNFR2 interaction is critical for the activation, expansion and functional stability of Tregs. However, we showed that the expression of TNFR2 was also up-regulated on CD4+ Foxp3− effector T cells (Teffs) upon TCR stimulation. In order to define the role of TNFR2 in the pathogenic CD4 T cells, we compared the effect of transferred naïve CD4 cells from WT mice and TNFR2−/− mice into Rag 1−/− recipients. Transfer of TNFR2-deficient Teff cells failed to induce full-fledged colitis, unlike WT Teffs. This was due to defective proliferative expansion of TNFR2-deficient Teff cells in the lymphopenic mice, as well as their reduced capacity to express proinflammatory Th1 cytokine on a per cell basis. In vitro, the proliferative response of TNFR2 deficient naïve CD4 cells to anti-CD3 stimulation was markedly decreased as compared with that of WT naïve CD4 cells. The hypoproliferative response of TNFR2- deficient Teff cells to TCR stimulation was associated with an increased ratio of p100/p52, providing a mechanistic basis for our findings. Therefore, this study clearly indicates that TNFR2 is important for the proliferative expansion of pathogenic Teff cells.

WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000385189200001
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China
2.Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States
3.School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xin Chen,,Yingjie Nie,Haitao Xiao,et al. Corrigendum: TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis[J]. SCIENTIFIC REPORTS,2016,6.
APA Xin Chen,.,Yingjie Nie.,Haitao Xiao.,Zhaoxiang Bian.,Anthony J. Scarzello.,...&Joost J. Oppenheim.(2016).Corrigendum: TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis.SCIENTIFIC REPORTS,6.
MLA Xin Chen,,et al."Corrigendum: TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis".SCIENTIFIC REPORTS 6(2016).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xin Chen,]'s Articles
[Yingjie Nie]'s Articles
[Haitao Xiao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xin Chen,]'s Articles
[Yingjie Nie]'s Articles
[Haitao Xiao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xin Chen,]'s Articles
[Yingjie Nie]'s Articles
[Haitao Xiao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.