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The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review
Suhana Ahmad1; Nor Azrini Azid1; Jennifer C. Boer2; JitKang Lim3; Xin Chen4; Magdalena Plebansk5; Rohimah Mohamud1,6
2018-11
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume9
Abstract

Tumor necrosis factor-alpha (TNF) is a pleiotropic cytokine, which is thought to play a major role in the pathogenesis of inflammatory diseases, including allergy. TNF is produced at the early stage of allergen sensitization, and then continues to promote the inflammation cascade in the effector phase of allergic reactions. Consequently, antiTNF treatment has been proposed as a potential therapeutic option. However, recent studies reveal anti-intuitive effects of TNF in the activation and proliferative expansion of immunosuppressive Tregs, tolerogenic DCs and MDSCs. This immunosuppressive effect of TNF is mediated by TNFR2, which is preferentially expressed by immunosuppressive cells. These findings redefine the role of TNF in allergic reaction, and suggest that targeting TNF-TNFR2 interaction itself may represent a novel strategy in the treatment of allergy.

KeywordAllergy Tnf Tnfr2 Regulatory t Cells Tolerogenic Dendritic Cells
DOIhttp://doi.org/10.3389/fimmu.2018.02572
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000449653500001
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorRohimah Mohamud
Affiliation1.Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
2.Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia
3.School of Chemical Engineering, Universiti Sains Malaysia, Pulau Pinang, Malaysia
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, China
5.School of Health and Biomedical Sciences, RMIT, Melbourne, VIC,Australia
6.Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, Malaysia
Recommended Citation
GB/T 7714
Suhana Ahmad,Nor Azrini Azid,Jennifer C. Boer,et al. The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review[J]. FRONTIERS IN IMMUNOLOGY,2018,9.
APA Suhana Ahmad.,Nor Azrini Azid.,Jennifer C. Boer.,JitKang Lim.,Xin Chen.,...&Rohimah Mohamud.(2018).The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review.FRONTIERS IN IMMUNOLOGY,9.
MLA Suhana Ahmad,et al."The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review".FRONTIERS IN IMMUNOLOGY 9(2018).
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