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Chemical and pharmacological studies of Oplopanax horridus , a North American botanical
Tyler Calway1; Guang-Jian Du1; Chong-Zhi Wang1; Wei-Hua Huang2; Jing Zhao2; Shao- Ping Li2; Chun-Su Yuan1
2012-04
Source PublicationJournal of natural medicines
ISSN1340-3443
Volume66Issue:2Pages:249–256
Abstract

Oplopanax horridus (OH) or Devil's club is an ethnobotanical used by the indigenous people native to the Pacific Northwest. There are three species in the genus Oplopanax, and OH is the only species that is distributed in North America. Compared with the extensive research on OH's “cousin,” American ginseng, there is comparatively little about the chemical makeup and pharmacological effects of OH. Nevertheless, there has been some research over the past few years that shows promise for future usage perspectives of OH. To date, seventeen compounds were isolated and elucidated including polyynes, glycosides, lignans, and polyenes, with most of the attention being paid to the polyynes. GC and HPLC were used to determine the contents of volatile compounds and polyynes in the essential oil and extracts of OH. For the pharmacological studies, antibacterial and anti-diabetes effects of polyynes were reported. Our recent study has focused more on the anticancer effects of OH and the involved mechanisms of action. In this review, we will summarize the research status in the botany, phytochemistry and pharmacology of OH.

KeywordOplopanax Horridus Devil's Club Polyynes Phytochemistry Pharmacology Anticancer
DOIhttp://doi.org/10.1007/s11418-011-0602-2
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000301483500001
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Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorShao- Ping Li; Chun-Su Yuan
Affiliation1.Tang Center for Herbal Medicine Research, and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA
2.State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Macao, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Tyler Calway,Guang-Jian Du,Chong-Zhi Wang,et al. Chemical and pharmacological studies of Oplopanax horridus , a North American botanical[J]. Journal of natural medicines,2012,66(2):249–256.
APA Tyler Calway.,Guang-Jian Du.,Chong-Zhi Wang.,Wei-Hua Huang.,Jing Zhao.,...&Chun-Su Yuan.(2012).Chemical and pharmacological studies of Oplopanax horridus , a North American botanical.Journal of natural medicines,66(2),249–256.
MLA Tyler Calway,et al."Chemical and pharmacological studies of Oplopanax horridus , a North American botanical".Journal of natural medicines 66.2(2012):249–256.
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