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Smad linker region phosphorylation in the regulation of extracellular matrix synthesis
Burch, ML1,2,3; Zheng, WH4; Little, PJ1,2,3
2011
Source PublicationCELLULAR AND MOLECULAR LIFE SCIENCES
ISSN1420-682X
Volume68Issue:1Pages:97-107
Abstract

The canonical TGF-beta signalling pathway involves Smad transcription factors through direct serine phosphorylation of the carboxy termini, nuclear translocation and regulation of transcription by receptor-regulated (R)-Smad complexes. Smads can also be phosphorylated in the linker region most prominently by the action of mitogen-activated protein (MAP) kinases, which in turn have been activated by TGF-beta or a multitude of other growth factors and hormones. Linker regionphosphorylation can prevent nuclear translocation of Smads and inhibit TGF-beta signalling, potentially leading to oncogenesis. However, some evidence has revealed that linker regionphosphorylated Smads can be translocated to the nucleus where they regulate transcription particularly of the synthesis of extracellular matrix molecules. Matrix molecules such as collagen and proteoglycans are involved in diseases such a fibrosis and atherosclerosis, respectively, and theinvolvement of linker region phosphorylation may represent a new therapeutic target.

KeywordTransforming Growth Factor-beta Phosphorylation Signalling Vascular Smooth Muscle Collagen Proteoglycans Smads
DOIhttps://dx.doi.org/10.1007/s00018-010-0514-4
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000285786600008
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Cited Times [WOS]:46   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.BakerIDI Heart & Diabet Inst, Diabet & Cell Biol Lab, Melbourne, Vic 3004, Australia
2.Monash Univ, Sch Med, Dept Med, Cent & Eastern Clin Sch, Prahran, Vic 3004, Australia
3.Monash Univ, Sch Med, Dept Immunol, Cent & Eastern Clin Sch, Prahran, Vic 3004, Australia
4.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Burch, ML,Zheng, WH,Little, PJ. Smad linker region phosphorylation in the regulation of extracellular matrix synthesis[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2011,68(1):97-107.
APA Burch, ML,Zheng, WH,&Little, PJ.(2011).Smad linker region phosphorylation in the regulation of extracellular matrix synthesis.CELLULAR AND MOLECULAR LIFE SCIENCES,68(1),97-107.
MLA Burch, ML,et al."Smad linker region phosphorylation in the regulation of extracellular matrix synthesis".CELLULAR AND MOLECULAR LIFE SCIENCES 68.1(2011):97-107.
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