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Forkhead box O transcription factors as possible mediators in the development of major depression
Wang, HT1,2; Quirion, R3; Little, PJ4; Cheng, YF1; Feng, ZP5; Sun, HS5; Xu, JP1; Zheng, WH2
2015
Source PublicationNEUROPHARMACOLOGY
ISSN0028-3908
Volume99Pages:527-537
Abstract

Forkhead box O (FoxO) transcription factors play important roles in cellular physiology and biology. Recent findings indicate that FoxOs are also involved in the development of major depressive disorder. Alterations in the upstream molecules of FoxOs, such as brain derived neurotrophic factor or protein kinase B, have been linked to depression. Antidepressants, such as imipramine and venlafaxine, modify the FoxOs phosphorylation. Furthermore, FoxOs could be regulated by serotonin and norepinephrine receptor signaling as well as the hypothalamic pituitary adrenal axis, all of which are involved in the pathogenesis of depression. FoxOs also regulate neuronal morphology, synaptogenesis and adult hippocampal neurogenesis, which are viewed as candidate mechanisms for the etiology of depression. In this review, we emphasize the possible roles of FoxOs during thedevelopment of depression and make some strategic recommendations for future research. We propose that FoxOs and its signaling pathways may constitute potential therapeutic targets in thetreatment of depression. (C) 2015 Elsevier Ltd. All rights reserved.

KeywordFoxo Neurogenesis Neuronal Atrophy Major Depression Pi3k/akt
DOIhttps://dx.doi.org/10.1016/j.neuropharm.2015.08.020
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy
WOS SubjectNeurosciences ; Pharmacology & Pharmacy
WOS IDWOS:000366066800050
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Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
2.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
3.McGill Univ, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada
4.Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia
5.Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang, HT,Quirion, R,Little, PJ,et al. Forkhead box O transcription factors as possible mediators in the development of major depression[J]. NEUROPHARMACOLOGY,2015,99:527-537.
APA Wang, HT.,Quirion, R.,Little, PJ.,Cheng, YF.,Feng, ZP.,...&Zheng, WH.(2015).Forkhead box O transcription factors as possible mediators in the development of major depression.NEUROPHARMACOLOGY,99,527-537.
MLA Wang, HT,et al."Forkhead box O transcription factors as possible mediators in the development of major depression".NEUROPHARMACOLOGY 99(2015):527-537.
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