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A Review on Bradykinin-Related Peptides Isolated from Amphibian Skin Secretion
Xi, XP1; Li, Bin1; Chen, TB2; Kwok, HF1,2
2015
Source PublicationTOXINS
ISSN2072-6651
Volume7Issue:3Pages:951-970
Abstract

Amphibian skin secretion has great potential for drug discovery and contributes hundreds of bioactive peptides including bradykinin-related peptides (BRPs). More than 50 BRPs have been reported in the last two decades arising from the skin secretion of amphibian species. They belong to the families Ascaphidae (1 species), Bombinatoridae (3 species), Hylidae (9 speices) and Ranidae (25 species). This paper presents the diversity of structural characteristics of BRPs with N-terminal, C-terminal extension and amino acid substitution. The further comparison of cDNA-encoded prepropeptides between the different species and families demonstrated that there are various forms of kininogen precursors to release BRPs and they constitute important evidence in amphibianevolution. The pharmacological activities of isolated BRPs exhibited unclear structure-function relationships, and therefore the scope for drug discovery and development is limited. However, their diversity shows new insights into biotechnological applications and, as a result, comprehensive and systematic studies of the physiological and pharmacological activities of BRPs from amphibian skinsecretion are needed in the future.

KeywordAmphibian Bradykinin Agonist And antAgonist Biosynthetic Kininogen Bradykinin-related Peptide
DOIhttp://dx.doi.org/10.3390/toxins7030951
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000359339500021
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Univ Macau, Fac Hlth Sci, Taipa, Macau SAR, Peoples R China
2.Queens Univ Belfast, Sch Pharm, Nat Drug Discovery Grp, Belfast BT9 7BL, Antrim, North Ireland
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Xi, XP,Li, Bin,Chen, TB,et al. A Review on Bradykinin-Related Peptides Isolated from Amphibian Skin Secretion[J]. TOXINS,2015,7(3):951-970.
APA Xi, XP,Li, Bin,Chen, TB,&Kwok, HF.(2015).A Review on Bradykinin-Related Peptides Isolated from Amphibian Skin Secretion.TOXINS,7(3),951-970.
MLA Xi, XP,et al."A Review on Bradykinin-Related Peptides Isolated from Amphibian Skin Secretion".TOXINS 7.3(2015):951-970.
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