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Recent advances in the field of anti-cancer immunotherapy
Neves, H; Kwok, HF
2015
Source PublicationBBA CLINICAL
ISSN2214-6474
Volume3Pages:280-288
Abstract

Background: The main goal of anti-cancer therapy is to specifically inhibit the malignant activity ofcancer cells, while leaving healthy cells unaffected. As such, for every proposed therapy, it is important to keep in mind the therapeutic index-the ratio of the toxic dose over the therapeutic dose. The use of immunotherapy has allowed a means to both specifically block protein-protein interaction and deliver cytotoxic events to a tumor-specific antigen. 

Review scope: It is the objective of this review to give an overview on current immunotherapytreatment for cancers using monoclonal antibodies. We demonstrate three exciting targets for immunotherapy, TNF-alpha Converting Enzyme (TACE), Cathepsin S and Urokinase Plasmogen Activator and go over the advances made with one of the most used monoclonal antibodies in cancer therapy, Rituximab; as well as Herceptin, which is used for breast cancer therapy. Furthermore, we touch on other venues of immunotherapy, such as adaptive cell transfer, the use of nucleic acids and the use of dendritic cells. Finally, we summarize some ongoing studies that spell tentative advancements for anti-cancer immunotherapy. 

General significance: Immunotherapy is at the forefront of anti-cancer therapies, allying both a high degree of specificity to general high effectiveness and fewer side-effects. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

KeywordImmunotherapy Anti-cancer Therapies Antibodies Cancer
DOIhttp://dx.doi.org/10.1016/j.bbacli.2015.04.001
Indexed BySCI
Language英语
WOS Research AreaGeneral & Internal Medicine
WOS SubjectGeneral & Internal Medicine
WOS IDWOS:000361122900035
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniv Macau, Fac Hlth Sci, Ave Univ, Taipa, Macau, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Neves, H,Kwok, HF. Recent advances in the field of anti-cancer immunotherapy[J]. BBA CLINICAL,2015,3:280-288.
APA Neves, H,&Kwok, HF.(2015).Recent advances in the field of anti-cancer immunotherapy.BBA CLINICAL,3,280-288.
MLA Neves, H,et al."Recent advances in the field of anti-cancer immunotherapy".BBA CLINICAL 3(2015):280-288.
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