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Chromosome-centric Human Proteome Project (C-HPP): Chromosome 12
Sakdithep Chaiyarit1; Nilubon Singhto1; Yi-Ju Chen2; Chia-Ying Cheng3; Wararat Chiangjong1; Rattiyaporn Kanlaya1; Henry H. N. Lam4; Paleerath Peerapen1; Ting-Yi Sung3; Phornpimon Tipthara1; Akhilesh Pandey5,6; Terence C. W. Poon7; Yu-Ju Chen2; Ravi Sirdeshmukh5; Maxey C. M. Chung8,9; Visith Thongboonkerd1,10
2014
Source PublicationJournal of Proteome Research
ISSN1535-3893
Volume13Issue:7Pages:3160-3165
Abstract

Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12- encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).

KeywordB/d-hpp C-hpp Chromosome 12 Chromosome-centric Hpp Hupo Human Proteome Organization Human Proteome Project
DOIhttps://doi.org/10.1021/pr500009j
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemical Research Methods
WOS IDWOS:000338693400003
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorVisith Thongboonkerd
Affiliation1.Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok 10700, Thailand
2.Institute of Chemistry, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan
3.Institute of Information Science, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan
4.Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
5.Institute of Bioinformatics, International Technology Park, Pattandur Agrahara, Whitefield, 560066 Bangalore, India
6.McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 33 North Broadway, Baltimore, Maryland 21205, United States
7.Department of Paediatrics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin New Territories, Hong Kong
8.Department of Biological Sciences, Faculty of Science, National University of Singapore, 14 Science Drive 4, 117543 Singapore
9.Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599 Singapore
10.Center for Research in Complex Systems Science, Mahidol University, Bangkok, Thailand
Recommended Citation
GB/T 7714
Sakdithep Chaiyarit,Nilubon Singhto,Yi-Ju Chen,et al. Chromosome-centric Human Proteome Project (C-HPP): Chromosome 12[J]. Journal of Proteome Research,2014,13(7):3160-3165.
APA Sakdithep Chaiyarit.,Nilubon Singhto.,Yi-Ju Chen.,Chia-Ying Cheng.,Wararat Chiangjong.,...&Visith Thongboonkerd.(2014).Chromosome-centric Human Proteome Project (C-HPP): Chromosome 12.Journal of Proteome Research,13(7),3160-3165.
MLA Sakdithep Chaiyarit,et al."Chromosome-centric Human Proteome Project (C-HPP): Chromosome 12".Journal of Proteome Research 13.7(2014):3160-3165.
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