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Recent Insights into the Biological Activities and Drug Delivery Systems of Tanshinones
Yuee Cai1; Wenji Zhang2; Zirong Chen3; Zhi Shi1,2; Chengwei He1; Meiwan Chen1
2016-01-05
Source PublicationInternational Journal of Nanomedicine
ISSN1176-9114
Volume2016Issue:11Pages:121—130
Abstract

Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the prospective biomedical applications of these compounds. Numerous pharmacological activities, including anti-inflammatory, anticancer, and cardio-cerebrovascular protection activities, are exhibited by the three primary bioactive constituents among the tanshinones, ie, tanshinone I (TNI), tanshinone IIA (TNIIA), and cryptotanshinone (CPT). However, due to their poor solubility and low dissolution rate, the clinical applications of TNI, TNIIA, and CPT are limited. To solve these problems, many studies have focused on loading tanshinones into liposomes, nanoparticles, microemulsions, cyclodextrin inclusions, solid dispersions, and so on. In this review, we aim to offer an updated summary of the biological activities and drug delivery systems of tanshinones to provide a reference for these constituents in clinical applications.

KeywordTanshinones Biological Activities Drug Delivery Systems Bioavailability Solubility
DOIhttps://dx.doi.org/10.2147/IJN.S84035
Language英语
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000367725100001
PublisherDOVE MEDICAL PRESS LTD, PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
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Cited Times [WOS]:32   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMeiwan Chen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China
2.Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People’s Republic of China
3.Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, FL, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yuee Cai,Wenji Zhang,Zirong Chen,et al. Recent Insights into the Biological Activities and Drug Delivery Systems of Tanshinones[J]. International Journal of Nanomedicine,2016,2016(11):121—130.
APA Yuee Cai,Wenji Zhang,Zirong Chen,Zhi Shi,Chengwei He,&Meiwan Chen.(2016).Recent Insights into the Biological Activities and Drug Delivery Systems of Tanshinones.International Journal of Nanomedicine,2016(11),121—130.
MLA Yuee Cai,et al."Recent Insights into the Biological Activities and Drug Delivery Systems of Tanshinones".International Journal of Nanomedicine 2016.11(2016):121—130.
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